InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Jmjd6

Summary

InnateDB Gene

IDBG-214522.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jmjd6

Gene Name

jumonji domain containing 6

Synonyms

5730436I23Rik; D11Ertd195e; mKIAA0585; PSR; PtdSerR; Ptdsr

Species

Mus musculus

Ensembl Gene

ENSMUSG00000056962

Encoded Proteins

IDBP-214524

jumonji domain containing 6

IDBP-536990

jumonji domain containing 6

IDBP-542240

jumonji domain containing 6

IDBP-533900

jumonji domain containing 6

IDBP-539939

jumonji domain containing 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26221041

[Homo sapiens] Reversible arginine methylation of TRAF6 is regulated by PRMT1 and JMJD6 and this in turn regulates TRAF6-dependent TLR signalling.

Entrez Gene

Summary

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein functions in differentiation of multiple tissues during development, and in anti-inflammatory cytokine signaling. It was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that this protein does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:116837432-116843449

Strand

Reverse strand

Band

Transcripts

ENSMUST00000047616	ENSMUSP00000047570
ENSMUST00000141735
ENSMUST00000142495	ENSMUSP00000117922
ENSMUST00000130120
ENSMUST00000124831	ENSMUSP00000122867
ENSMUST00000140349	ENSMUSP00000120850
ENSMUST00000140513	ENSMUSP00000115086

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003727	single-stranded RNA binding
GO:0004872	receptor activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0033746	histone demethylase activity (H3-R2 specific)
GO:0033749	histone demethylase activity (H4-R3 specific)
GO:0042802	identical protein binding
GO:0070815	peptidyl-lysine 5-dioxygenase activity

Biological Process

GO:0001568	blood vessel development
GO:0001822	kidney development
GO:0002040	sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007166	cell surface receptor signaling pathway
GO:0007507	heart development
GO:0008380	RNA splicing
GO:0018395	peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
GO:0030324	lung development
GO:0033077	T cell differentiation in thymus
GO:0042116	macrophage activation
GO:0043277	apoptotic cell clearance
GO:0043654	recognition of apoptotic cell
GO:0048024	regulation of mRNA splicing, via spliceosome
GO:0048821	erythrocyte development
GO:0055114	oxidation-reduction process
GO:0060041	retina development in camera-type eye
GO:0070078	histone H3-R2 demethylation
GO:0070079	histone H4-R3 demethylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000070495

View Gene Order

ENSBTAG00000019153

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.383423 Mm.436739 Mm.481684

RefSeq

NM_033398

OMIM

CCDS

CCDS25678

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas