Mus musculus Gene: Jmjd6
Summary
InnateDB Gene IDBG-214522.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Jmjd6
Gene Name jumonji domain containing 6
Synonyms 5730436I23Rik; D11Ertd195e; mKIAA0585; PSR; PtdSerR; Ptdsr;
Species Mus musculus
Ensembl Gene ENSMUSG00000056962
Encoded Proteins
jumonji domain containing 6
jumonji domain containing 6
jumonji domain containing 6
jumonji domain containing 6
jumonji domain containing 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] Reversible arginine methylation of TRAF6 is regulated by PRMT1 and JMJD6 and this in turn regulates TRAF6-dependent TLR signalling.
Entrez Gene
Summary This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein functions in differentiation of multiple tissues during development, and in anti-inflammatory cytokine signaling. It was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that this protein does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:116837432-116843449
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000047616 ENSMUSP00000047570
ENSMUST00000141735
ENSMUST00000142495 ENSMUSP00000117922
ENSMUST00000130120
ENSMUST00000124831 ENSMUSP00000122867
ENSMUST00000140349 ENSMUSP00000120850
ENSMUST00000140513 ENSMUSP00000115086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003727 single-stranded RNA binding
GO:0004872 receptor activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0033746 histone demethylase activity (H3-R2 specific)
GO:0033749 histone demethylase activity (H4-R3 specific)
GO:0042802 identical protein binding
GO:0070815 peptidyl-lysine 5-dioxygenase activity
Biological Process
GO:0001568 blood vessel development
GO:0001822 kidney development
GO:0002040 sprouting angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0007166 cell surface receptor signaling pathway
GO:0007507 heart development
GO:0008380 RNA splicing
GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
GO:0030324 lung development
GO:0033077 T cell differentiation in thymus
GO:0042116 macrophage activation
GO:0043277 apoptotic cell clearance
GO:0043654 recognition of apoptotic cell
GO:0048024 regulation of mRNA splicing, via spliceosome
GO:0048821 erythrocyte development
GO:0055114 oxidation-reduction process
GO:0060041 retina development in camera-type eye
GO:0070078 histone H3-R2 demethylation
GO:0070079 histone H4-R3 demethylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.383423 Mm.436739 Mm.481684
RefSeq NM_033398
OMIM
CCDS CCDS25678
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas