Mus musculus Gene: Birc5
Summary
InnateDB Gene IDBG-214593.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Birc5
Gene Name baculoviral IAP repeat-containing 5
Synonyms AAC-11; Api4; survivin40; TIAP;
Species Mus musculus
Ensembl Gene ENSMUSG00000017716
Encoded Proteins
baculoviral IAP repeat-containing 5
baculoviral IAP repeat-containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] BIRC5 is cleaved by GZMM (granzyme M) and this triggers degradation of the BIRC5-XIAP complex to free caspase activity, leading to cytolysis of target cells.
Entrez Gene
Summary This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene\'s expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:117849251-117855743
Strand Forward strand
Band E2
Transcripts
ENSMUST00000081387 ENSMUSP00000079124
ENSMUST00000093906 ENSMUSP00000091433
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0015631 tubulin binding
GO:0042803 protein homodimerization activity
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0048037 cofactor binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000226 microtubule cytoskeleton organization
GO:0000910 cytokinesis
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007346 regulation of mitotic cell cycle
GO:0031503 protein complex localization
GO:0031536 positive regulation of exit from mitosis
GO:0031577 spindle checkpoint
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0051301 cell division
GO:0051303 establishment of chromosome localization
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061469 regulation of type B pancreatic cell proliferation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0005881 cytoplasmic microtubule
GO:0030496 midbody
GO:0031021 interphase microtubule organizing center
GO:0032133 chromosome passenger complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell Cycle, Mitotic pathway
Separation of Sister Chromatids pathway
Resolution of Sister Chromatid Cohesion pathway
Cell Cycle pathway
M Phase pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Prometaphase pathway
Mitotic Anaphase pathway
KEGG
Pathways in cancer pathway
Colorectal cancer pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
M Phase pathway
Separation of Sister Chromatids pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Cell Cycle pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
KEGG
Pathways in cancer pathway
Colorectal cancer pathway
INOH
PID BIOCARTA
B cell survival pathway [Biocarta view]
PID NCI
Aurora A signaling
Validated targets of C-MYC transcriptional activation
Aurora B signaling
FOXM1 transcription factor network
Cross-References
SwissProt O70201
TrEMBL
UniProt Splice Variant
Entrez Gene 11799
UniGene Mm.403608 Mm.8552
RefSeq NM_001012273 NM_009689
OMIM
CCDS CCDS25695 CCDS25694
HPRD
IMGT
MGI ID MGI:1203517
MGI Symbol Birc5
EMBL AB013819 AF077349 AF115517 BC004702
GenPept AAD26199 AAD26200 AAD26201 AAD34225 AAH04702 BAA28266
RNA Seq Atlas 11799