Version 5.4
Mus musculus Gene: Cyth1
Summary
InnateDB Gene IDBG-214627.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyth1
Gene Name cytohesin 1
Synonyms CLM1; CTH-1; CYTIP; mKIAA4240; Pscd1
Species Mus musculus
Ensembl Gene ENSMUSG00000017132
Encoded Proteins
IDBP-214629
cytohesin 1
IDBP-214631
cytohesin 1
IDBP-269044
cytohesin 1
IDBP-269048
cytohesin 1
IDBP-538748
cytohesin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108669:
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2. [provided by RefSeq, Aug 2008]
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:118132019-118248592
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000017276 ENSMUSP00000017276
ENSMUST00000100181 ENSMUSP00000097756
ENSMUST00000106305 ENSMUSP00000101912
ENSMUST00000106302 ENSMUSP00000101909
ENSMUST00000141243
ENSMUST00000131115
ENSMUST00000151165 ENSMUSP00000114792
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0030155 regulation of cell adhesion
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
GO:0090162 establishment of epithelial cell polarity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108669
View Gene Order
ENSBTAG00000006663
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q9QX11
TrEMBL A2A517 B1AQE4 Q3TZ02 Q8K3E8 Q9ESS4
UniProt Splice Variant
Entrez Gene 19157
UniGene
RefSeq NM_001112699 NM_001112700 NM_011180 XM_006532515 XM_006532516 XM_006532518 XM_006532519 XM_006532520
OMIM
CCDS CCDS48995 CCDS48996 CCDS48997
HPRD
IMGT
MGI ID MGI:1334257
MGI Symbol Cyth1
EMBL AB013464 AB035537 AB035538 AF051337 AK158216 AL591109 AL591204 AL591404 AY126516 BC057974 CH466558
GenPept AAC71694 AAH57974 AAM95454 BAA33428 BAB13509 BAB13511 BAE34408 EDL34652 EDL34653
RNA Seq Atlas 19157

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca