InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Timp2

Summary

InnateDB Gene

IDBG-214632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Timp2

Gene Name

tissue inhibitor of metalloproteinase 2

Synonyms

D11Bwg1104e; Timp-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017466

Encoded Proteins

IDBP-214634

tissue inhibitor of metalloproteinase 2

IDBP-540786

tissue inhibitor of metalloproteinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000035862:
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:118301069-118355740

Strand

Reverse strand

Band

Transcripts

ENSMUST00000017610	ENSMUSP00000017610
ENSMUST00000155707	ENSMUSP00000122642

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008191	metalloendopeptidase inhibitor activity

Biological Process

GO:0007417	central nervous system development
GO:0007568	aging
GO:0008285	negative regulation of cell proliferation
GO:0010951	negative regulation of endopeptidase activity
GO:0030814	regulation of cAMP metabolic process
GO:0032487	regulation of Rap protein signal transduction
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0043408	regulation of MAPK cascade
GO:0043410	positive regulation of MAPK cascade
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045762	positive regulation of adenylate cyclase activity
GO:0045861	negative regulation of proteolysis
GO:0045930	negative regulation of mitotic cell cycle
GO:0046580	negative regulation of Ras protein signal transduction
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0009986	cell surface
GO:0030426	growth cone
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000035862

View Gene Order

ENSBTAG00000010899

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118682

Activation of Matrix Metalloproteinases pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

B1AQJ3 Q6GXA8 Q6PI17

UniProt Splice Variant

Entrez Gene

21858

UniGene

Mm.206505 Mm.487859

RefSeq

NM_011594

OMIM

CCDS

CCDS25699

HPRD

IMGT

MGI ID

MGI:98753

MGI Symbol

Timp2

EMBL

AL591404 AY622854 BC049126 CH466558

GenPept

AAH49126 AAT46409 EDL34658

RNA Seq Atlas

21858