Mus musculus Gene: Rptor
Summary
InnateDB Gene IDBG-214724.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rptor
Gene Name regulatory associated protein of MTOR, complex 1
Synonyms 4932417H02Rik; mKIAA1303; Rap; Raptor;
Species Mus musculus
Ensembl Gene ENSMUSG00000025583
Encoded Proteins
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141564:
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:119602905-119899576
Strand Forward strand
Band E2
Transcripts
ENSMUST00000026671 ENSMUSP00000026671
ENSMUST00000125583
ENSMUST00000130049
ENSMUST00000147772
ENSMUST00000147781 ENSMUSP00000124366
ENSMUST00000127899
ENSMUST00000139728 ENSMUSP00000124886
ENSMUST00000126802
ENSMUST00000124401 ENSMUSP00000125503
ENSMUST00000136662 ENSMUSP00000125293
ENSMUST00000148860
ENSMUST00000131217 ENSMUSP00000125667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001030 RNA polymerase III type 1 promoter DNA binding
GO:0001031 RNA polymerase III type 2 promoter DNA binding
GO:0001032 RNA polymerase III type 3 promoter DNA binding
GO:0001156 TFIIIC-class transcription factor binding
GO:0005488 binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0008361 regulation of cell size
GO:0016049 cell growth
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0042325 regulation of phosphorylation
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0071230 cellular response to amino acid stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0030425 dendrite
GO:0031931 TORC1 complex
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
mTOR signaling pathway pathway
Insulin signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Cellular responses to stress pathway
PKB-mediated events pathway
mTOR signalling pathway
Release of eIF4E pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
mTORC1-mediated signalling pathway
Signal Transduction pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
S6K1-mediated signalling pathway
Insulin receptor signalling cascade pathway
HSF1-dependent transactivation pathway
IRS-related events triggered by IGF1R pathway
Cellular response to heat stress pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Signaling by Insulin receptor pathway
Regulation of AMPK activity via LKB1 pathway
KEGG
mTOR signaling pathway pathway
Insulin signaling pathway pathway
INOH
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
mTOR signaling pathway
LKB1 signaling events
Cross-References
SwissProt
TrEMBL E9PXZ5 F6U5L3
UniProt Splice Variant
Entrez Gene 74370
UniGene Mm.209933
RefSeq XM_006534364 NM_028898 XM_006534362
OMIM
CCDS CCDS25720
HPRD
IMGT
MGI ID MGI:1921620
MGI Symbol Rptor
EMBL AL669881 AL928989 AL929234 BX248132
GenPept
RNA Seq Atlas 74370