Mus musculus Gene: Rptor | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-214724.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Rptor | ||||||||||||||||||||||
Gene Name | regulatory associated protein of MTOR, complex 1 | ||||||||||||||||||||||
Synonyms | 4932417H02Rik; mKIAA1303; Rap; Raptor | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000025583 | ||||||||||||||||||||||
Encoded Proteins |
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
regulatory associated protein of MTOR, complex 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141564:
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 11:119602905-119899576 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | E2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
Insulin signaling pathway pathway
mTOR signaling pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Release of eIF4E pathway
S6K1-mediated signalling pathway
Regulation of AMPK activity via LKB1 pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Cellular responses to stress pathway
PKB-mediated events pathway
mTORC1-mediated signalling pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Insulin receptor signalling cascade pathway
HSF1-dependent transactivation pathway
Cellular response to heat stress pathway
IRS-related events pathway
IGF1R signaling cascade pathway
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KEGG |
mTOR signaling pathway pathway
Insulin signaling pathway pathway
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INOH |
Insulin receptor signaling pathway
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PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
mTOR signaling pathway
LKB1 signaling events
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.209933 | ||||||||||||||||||||||
RefSeq | NM_028898 XM_006534362 XM_006534364 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS25720 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||