InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: P4hb

Summary

InnateDB Gene

IDBG-214839.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4hb

Gene Name

prolyl 4-hydroxylase, beta polypeptide

Synonyms

ERp59; PDI; Pdia1; Thbp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025130

Encoded Proteins

IDBP-214841

prolyl 4-hydroxylase, beta polypeptide

IDBP-624227

prolyl 4-hydroxylase, beta polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185624:
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:120560298-120573253

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026122	ENSMUSP00000026122
ENSMUST00000166620
ENSMUST00000168360	ENSMUSP00000128796

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0019899	enzyme binding
GO:0031545	peptidyl-proline 4-dioxygenase activity
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006457	protein folding
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:0071456	cellular response to hypoxia
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005886	plasma membrane
GO:0016222	procollagen-proline 4-dioxygenase complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome