InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TUBB4A

Summary

InnateDB Gene

IDBG-21605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TUBB4A

Gene Name

tubulin, beta 4A class IVa

Synonyms

beta-5; DYT4; TUBB4; TUBB5

Species

Homo sapiens

Ensembl Gene

ENSG00000104833

Encoded Proteins

IDBP-21607

tubulin, beta 4A class IVa

IDBP-592869

tubulin, beta 4A class IVa

IDBP-765969

IDBP-759937

IDBP-765591

IDBP-759879

IDBP-761416

IDBP-763330

IDBP-766301

IDBP-764439

IDBP-765078

IDBP-765335

IDBP-759874

IDBP-765331

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:6494319-6502848

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000264071	ENSP00000264071
ENST00000540257	ENSP00000443590
ENST00000598006	ENSP00000472795
ENST00000596291	ENSP00000471880
ENST00000596926	ENSP00000468843
ENST00000598635	ENSP00000470627
ENST00000594276	ENSP00000472481
ENST00000601152	ENSP00000471320
ENST00000600216	ENSP00000470983
ENST00000594290	ENSP00000471503
ENST00000601640	ENSP00000469660
ENST00000597686	ENSP00000472375
ENST00000594075	ENSP00000469936
ENST00000595324	ENSP00000469560

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006457	protein folding
GO:0007017	microtubule-based process
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding
GO:0051258	protein polymerization
GO:0051297	centrosome organization

Cellular Component

GO:0000242	pericentriolar material
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005929	cilium
GO:0033269	internode region of axon
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043209	myelin sheath
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000062591

View Gene Order

Pathways

NETPATH

REACTOME

REACT_150425

Resolution of Sister Chromatid Cohesion pathway

REACT_682

Mitotic Prometaphase pathway

REACT_150471

Separation of Sister Chromatids pathway

REACT_160315

Regulation of PLK1 Activity at G2/M Transition pathway

REACT_15364

Loss of Nlp from mitotic centrosomes pathway

REACT_15451

Loss of proteins required for interphase microtubule organization�? from the centrosome pathway

REACT_15510

Recruitment of NuMA to mitotic centrosomes pathway

REACT_15296

Recruitment of mitotic centrosome proteins and complexes pathway

REACT_121399

MHC class II antigen presentation pathway

REACT_25201

Kinesins pathway

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_16967

Post-chaperonin tubulin folding pathway pathway

REACT_16936

Prefoldin mediated transfer of substrate to CCT/TriC pathway

REACT_16956

Formation of tubulin folding intermediates by CCT/TriC pathway

REACT_11039

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane pathway

REACT_11050

Transport of connexons to the plasma membrane pathway

REACT_9509

Gap junction assembly pathway

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_22365

Recycling pathway of L1 pathway

REACT_22205

L1CAM interactions pathway

REACT_16952

Protein folding pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_111045

Developmental Biology pathway

REACT_228134

Signaling by Hedgehog pathway

REACT_18266

Axon guidance pathway

REACT_111102

Signal Transduction pathway

REACT_267634

Hedgehog 'off' state pathway

REACT_9411

Gap junction trafficking pathway

REACT_17004

Chaperonin-mediated protein folding pathway

REACT_115566

Cell Cycle pathway

REACT_267716

Orphan transporters pathway

REACT_17015

Metabolism of proteins pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_17029

Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway

REACT_910

M Phase pathway

REACT_1275

Mitotic Anaphase pathway

REACT_15479

Centrosome maturation pathway

REACT_2203

G2/M Transition pathway

REACT_152

Cell Cycle, Mitotic pathway

REACT_21391

Mitotic G2-G2/M phases pathway

REACT_9480

Gap junction trafficking and regulation pathway

REACT_604

Hemostasis pathway

REACT_11123

Membrane Trafficking pathway

REACT_150314

Mitotic Metaphase and Anaphase pathway

KEGG

hsa05130

Pathogenic Escherichia coli infection pathway

hsa04540

Gap junction pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

M0R2D3

UniProt Splice Variant

Entrez Gene

10382

UniGene

Hs.110837

RefSeq

NM_001289123 NM_001289127 NM_001289129 NM_001289130 NM_001289131 NM_006087

HUGO

HGNC:20774

OMIM

602662

CCDS

CCDS12168

HPRD

04045

IMGT

EMBL

AC010503

GenPept

RNA Seq Atlas

10382