Homo sapiens Gene: IL4R
Summary
InnateDB Gene IDBG-21808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL4R
Gene Name interleukin 4 receptor
Synonyms CD124; IL-4RA; IL4RA;
Species Homo sapiens
Ensembl Gene ENSG00000077238
Encoded Proteins
interleukin 4 receptor
interleukin 4 receptor
interleukin 4 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IL4R is utilized by IL13 to induce phosphorylation and activation of JAK2 in human colon carcinoma cell lines.
The IL4R signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] The Il4ra signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis
Entrez Gene
Summary This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:27313668-27364778
Strand Forward strand
Band p12.1
Transcripts
ENST00000170630 ENSP00000170630
ENST00000395762 ENSP00000379111
ENST00000543915 ENSP00000441667
ENST00000561742 ENSP00000454725
ENST00000565915
ENST00000566117 ENSP00000455632
ENST00000563787
ENST00000568746 ENSP00000455714
ENST00000562968 ENSP00000456669
ENST00000565696
ENST00000565352 ENSP00000461268
ENST00000563002 ENSP00000456930
ENST00000563926 ENSP00000454684
ENST00000566318 ENSP00000456248
ENST00000563886
ENST00000562142 ENSP00000457131
ENST00000561946
ENST00000565179 ENSP00000461607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 37 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004913 interleukin-4 receptor activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
GO:0030728 ovulation
GO:0035556 intracellular signal transduction
GO:0035771 interleukin-4-mediated signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042832 defense response to protozoan
GO:0043032 positive regulation of macrophage activation
GO:0043627 response to estrogen
GO:0045087 innate immune response (InnateDB)
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL4 pathway
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
INOH
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
PID BIOCARTA
Il 4 signaling pathway [Biocarta view]
PID NCI
p73 transcription factor network
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.513457 Hs.742121
RefSeq NM_000418 NM_001257406 NM_001257407 NM_001257997 XM_005255305 XM_005255308 XM_006721043
HUGO
OMIM
CCDS CCDS10629 CCDS58441
HPRD 00990
IMGT
EMBL
GenPept
RNA Seq Atlas