Version 5.4
Homo sapiens Gene: CD81
Summary
InnateDB Gene IDBG-22455.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD81
Gene Name CD81 molecule
Synonyms CVID6; S5.7; TAPA1; TSPAN28
Species Homo sapiens
Ensembl Gene ENSG00000110651
Encoded Proteins
IDBP-22459
CD81 molecule
IDBP-22461
CD81 molecule
IDBP-601212
CD81 molecule
IDBP-583167
CD81 molecule
IDBP-596173
CD81 molecule
IDBP-591993
CD81 molecule
IDBP-594831
CD81 molecule
IDBP-586374
CD81 molecule
IDBP-595779
CD81 molecule
IDBP-591218
CD81 molecule
IDBP-597358
CD81 molecule
IDBP-586886
CD81 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25972472
[Mus musculus] Cd81 inhibits Rac1/Stat1 activation and negatively regulates the defence mechanisms to Listeria monocytogenes infection.
Entrez Gene
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:2376177-2397419
Strand Forward strand
Band p15.5
Transcripts
ENST00000263645 ENSP00000263645
ENST00000381036 ENSP00000370424
ENST00000475945 ENSP00000433178
ENST00000492627 ENSP00000437242
ENST00000493525 ENSP00000432497
ENST00000492252 ENSP00000432249
ENST00000464784 ENSP00000433904
ENST00000481687 ENSP00000432033
ENST00000468153
ENST00000481386
ENST00000530648 ENSP00000432723
ENST00000533417 ENSP00000435633
ENST00000527343 ENSP00000433767
ENST00000526072 ENSP00000431780
ENST00000524805
ENST00000530239
ENST00000531840
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 209 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 209 [view]
Protein-Protein 209 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0023026 MHC class II protein complex binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008104 protein localization
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0043128 positive regulation of 1-phosphatidylinositol 4-kinase activity
GO:0046488 phosphatidylinositol metabolic process
GO:0046718 viral entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
Cellular Component
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031982 vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037706
View Gene Order
ENSBTAG00000047495
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04662
B cell receptor signaling pathway pathway
hsa05144
Malaria pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.54457
RefSeq NM_004356
HUGO
OMIM
CCDS CCDS73240 CCDS7734
HPRD 08924
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca