Homo sapiens Gene: CD81
Summary
InnateDB Gene IDBG-22455.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD81
Gene Name CD81 molecule
Synonyms CVID6; S5.7; TAPA1; TSPAN28;
Species Homo sapiens
Ensembl Gene ENSG00000110651
Encoded Proteins
CD81 molecule
CD81 molecule
CD81 molecule
CD81 molecule
CD81 molecule
CD81 molecule
CD81 molecule
CD81 molecule
CD81 molecule
CD81 molecule
CD81 molecule
CD81 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cd81 inhibits Rac1/Stat1 activation and negatively regulates the defence mechanisms to Listeria monocytogenes infection.
Entrez Gene
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:2376177-2397419
Strand Forward strand
Band p15.5
Transcripts
ENST00000263645 ENSP00000263645
ENST00000381036 ENSP00000370424
ENST00000475945 ENSP00000433178
ENST00000492627 ENSP00000437242
ENST00000493525 ENSP00000432497
ENST00000492252 ENSP00000432249
ENST00000464784 ENSP00000433904
ENST00000481687 ENSP00000432033
ENST00000468153
ENST00000481386
ENST00000530648 ENSP00000432723
ENST00000533417 ENSP00000435633
ENST00000527343 ENSP00000433767
ENST00000526072 ENSP00000431780
ENST00000524805
ENST00000530239
ENST00000531840
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 209 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 209 [view]
Protein-Protein 209 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0023026 MHC class II protein complex binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008104 protein localization
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0043128 positive regulation of 1-phosphatidylinositol 4-kinase activity
GO:0046488 phosphatidylinositol metabolic process
GO:0046718 viral entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
Cellular Component
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031982 vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
BCR pathway
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
B cell receptor signaling pathway pathway
Malaria pathway
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
Beta1 integrin cell surface interactions
Alpha4 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL E9PPF5
UniProt Splice Variant
Entrez Gene 975
UniGene Hs.54457
RefSeq NM_004356
HUGO HGNC:1701
OMIM 186845
CCDS CCDS7734 CCDS73240
HPRD 08924
IMGT
EMBL AC124057 AC129929
GenPept
RNA Seq Atlas 975