Homo sapiens Gene: INSR
Summary
InnateDB Gene IDBG-22529.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INSR
Gene Name insulin receptor
Synonyms CD220; HHF5;
Species Homo sapiens
Ensembl Gene ENSG00000171105
Encoded Proteins
insulin receptor
insulin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:7112255-7294034
Strand Reverse strand
Band p13.2
Transcripts
ENST00000341500 ENSP00000342838
ENST00000302850 ENSP00000303830
ENST00000597211
ENST00000600492 ENSP00000473170
ENST00000598216
ENST00000593970
ENST00000601099
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 135 [view]
Protein-Protein 132 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005009 insulin-activated receptor activity
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031994 insulin-like growth factor I binding
GO:0031995 insulin-like growth factor II binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0051425 PTB domain binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001934 positive regulation of protein phosphorylation
GO:0003007 heart morphogenesis
GO:0005975 carbohydrate metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008544 epidermis development
GO:0009887 organ morphogenesis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019087 transformation of host cell by virus
GO:0023014 signal transduction by phosphorylation
GO:0030238 male sex determination
GO:0030335 positive regulation of cell migration
GO:0031017 exocrine pancreas development
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032869 cellular response to insulin stimulus
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042593 glucose homeostasis
GO:0043410 positive regulation of MAPK cascade
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045740 positive regulation of DNA replication
GO:0045821 positive regulation of glycolytic process
GO:0045840 positive regulation of mitosis
GO:0045995 regulation of embryonic development
GO:0046326 positive regulation of glucose import
GO:0046777 protein autophosphorylation
GO:0048639 positive regulation of developmental growth
GO:0051290 protein heterotetramerization
GO:0051897 positive regulation of protein kinase B signaling
GO:0060267 positive regulation of respiratory burst
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
SHC-related events pathway
SHC activation pathway
Insulin receptor recycling pathway
Signal Transduction pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IRS activation pathway
Signal attenuation pathway
Signaling by Insulin receptor pathway
KEGG
Adherens junction pathway
Insulin signaling pathway pathway
Type II diabetes mellitus pathway
Aldosterone-regulated sodium reabsorption pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
Insulin signaling pathway [Biocarta view]
Growth hormone signaling pathway [Biocarta view]
PID NCI
Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Insulin Pathway
Insulin-mediated glucose transport
Cross-References
SwissProt P06213
TrEMBL A4ZPI3 A4ZPI5 A4ZPI7 A4ZPI8 B4DTR7 Q2MKP2 Q2PJC1 Q2PJC3 Q2PJC4 Q2PJC5 Q4U0V1
UniProt Splice Variant
Entrez Gene 3643
UniGene Hs.694195
RefSeq NM_000208 NM_001079817 XM_006722744
HUGO HGNC:6091
OMIM 147670
CCDS CCDS12176 CCDS42487
HPRD 00975
IMGT
EMBL AB208861 AC010311 AC010526 AC010606 AC125387 AK300332 BC117172 DQ021481 DQ311687 DQ333191 DQ333192 DQ333193 DQ333194 DQ333196 EF207604 EF207607 EF207609 EF207611 EF207612 J03466 J05043 M10051 M23100 M24555 M27195 M27197 M29929 M29930 M32823 M32824 M32825 M32826 M32827 M32828 M32829 M32830 M32831 M32832 M32833 M32834 M32835 M32836 M32837 M32838 M32839 M32840 M32841 M32842 M32972 M76592 X02160
GenPept AAA59174 AAA59175 AAA59176 AAA59177 AAA59178 AAA59190 AAA59452 AAA86791 AAC37604 AAI17173 AAY44085 ABC46548 ABC46549 ABC46550 ABC46551 ABC46553 ABC55359 ABP68900 ABP68903 ABP68905 ABP68907 ABP73389 BAD92098 BAG62079 CAA26096
RNA Seq Atlas 3643