Homo sapiens Gene: CYP7A1
Summary
InnateDB Gene IDBG-22670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP7A1
Gene Name cytochrome P450, family 7, subfamily A, polypeptide 1
Synonyms CP7A; CYP7; CYPVII;
Species Homo sapiens
Ensembl Gene ENSG00000167910
Encoded Proteins
cytochrome P450, family 7, subfamily A, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:58490178-58500236
Strand Reverse strand
Band q12.1
Transcripts
ENST00000301645 ENSP00000301645
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0008123 cholesterol 7-alpha-monooxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0006699 bile acid biosynthetic process
GO:0006707 cholesterol catabolic process
GO:0006805 xenobiotic metabolic process
GO:0008206 bile acid metabolic process
GO:0016125 sterol metabolic process
GO:0042632 cholesterol homeostasis
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0070857 regulation of bile acid biosynthetic process
GO:0071333 cellular response to glucose stimulus
GO:0071397 cellular response to cholesterol
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Metabolism of lipids and lipoproteins pathway
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Bile acid and bile salt metabolism pathway
PPARA activates gene expression pathway
Cytochrome P450 - arranged by substrate type pathway
Orphan transporters pathway
Endogenous sterols pathway
Synthesis of bile acids and bile salts pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Biological oxidations pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Primary bile acid biosynthesis pathway
Steroid hormone biosynthesis pathway
PPAR signaling pathway pathway
Bile secretion pathway
INOH
Steroids metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P22680
TrEMBL
UniProt Splice Variant
Entrez Gene 1581
UniGene Hs.1644
RefSeq NM_000780
HUGO HGNC:2651
OMIM 118455
CCDS CCDS6171
HPRD
IMGT
EMBL BC101777 BC112184 L13460 M89647 M93133 X56088
GenPept AAA58423 AAA58435 AAA61350 AAI01778 AAI12185 CAA39568
RNA Seq Atlas 1581