Homo sapiens Gene: AKT1
Summary
InnateDB Gene IDBG-22709.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKT1
Gene Name v-akt murine thymoma viral oncogene homolog 1
Synonyms AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA;
Species Homo sapiens
Ensembl Gene ENSG00000142208
Encoded Proteins
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
v-akt murine thymoma viral oncogene homolog 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
AKT1 is a Ser/Thr protein kinase that plays a pivotal role in functional activation in macrophages. AKT1 specifically functions in phagocytosis, intracellular bacterial infection, LPS tolerance, production of inflammatory cytokines/mediators, and migration during macrophage-mediate innate immunity.
AKT1 activation is blocked by Bacillus anthracis, resulting in the opening of a connexin ATP release channel and induction of macrophage death. Constitutive activation of AKT1 interferes with inflammasome activation and IL1B production, which compromises antimicrobial immunity. (Demonstrated in murine model)
AKT1 functions downstream of TLR2-stimulation to induce the expression of the monocyte chemoattractant protein 1, CCL2. (Demonstrated in mice)
AKT1 is important for establishing the inflammatory microenvironment in the airway upon exposure to rhinovirus.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Akt1 is a Ser/Thr protein kinase that plays a pivotal role in functional activation in macrophages. Akt1 specifically functions in phagocytosis, intracellular bacterial infection, LPS tolerance, production of inflammatory cytokines/mediators, and migration during macrophage-mediate innate immunity.
[Mus musculus] Akt1 activation is blocked by Bacillus anthracis, resulting in the opening of a connexin ATP release channel and induction of macrophage death. Constitutive activation of Akt1 interferes with inflammasome activation and Il1b production, which compromises antimicrobial immunity.
[Mus musculus] Akt1 functions downstream of Tlr2-stimulation to induce the expression of the monocyte chemoattractant protein 1, Ccl2.
[Mus musculus] Lysophosphatidic acid plays an anti-inflammatory role in macrophages by diminishing lipopolysaccharide-induced phosphorylation of Mapk14 and Akt1, as well as Rela nuclear translocation.
[Mus musculus] The Akt1/Mir199a/Cav1 pathway is a regulator of innate immunity that is dysfunctional in cystic fibrosis macrophages contributing to lung hyper-inflammation.
Entrez Gene
Summary The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:104769349-104795751
Strand Reverse strand
Band q32.33
Transcripts
ENST00000349310 ENSP00000270202
ENST00000402615 ENSP00000385326
ENST00000407796 ENSP00000384293
ENST00000554581 ENSP00000451828
ENST00000553506
ENST00000557552
ENST00000555528 ENSP00000450688
ENST00000555458 ENSP00000451470
ENST00000554192 ENSP00000450681
ENST00000544168 ENSP00000443897
ENST00000554585 ENSP00000481526
ENST00000554848 ENSP00000451166
ENST00000554826
ENST00000556836
ENST00000555380 ENSP00000451290
ENST00000555926 ENSP00000451824
ENST00000557494
ENST00000553797
ENST00000610370
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 482 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 482 [view]
Protein-Protein 477 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0042802 identical protein binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0001649 osteoblast differentiation
GO:0001893 maternal placenta development
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005979 regulation of glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006412 translation
GO:0006417 regulation of translation
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006809 nitric oxide biosynthetic process
GO:0006915 apoptotic process
GO:0006924 activation-induced cell death of T cells
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007281 germ cell development
GO:0007568 aging
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008637 apoptotic mitochondrial changes
GO:0009408 response to heat
GO:0009725 response to hormone
GO:0010467 gene expression
GO:0010507 negative regulation of autophagy
GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport
GO:0010765 positive regulation of sodium ion transport
GO:0010907 positive regulation of glucose metabolic process
GO:0010951 negative regulation of endopeptidase activity
GO:0010975 regulation of neuron projection development
GO:0015758 glucose transport
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0016310 phosphorylation
GO:0016567 protein ubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0030030 cell projection organization
GO:0030154 cell differentiation
GO:0030163 protein catabolic process
GO:0030168 platelet activation
GO:0030212 hyaluronan metabolic process
GO:0030307 positive regulation of cell growth
GO:0030334 regulation of cell migration
GO:0031018 endocrine pancreas development
GO:0031295 T cell costimulation
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0032094 response to food
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032287 peripheral nervous system myelin maintenance
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0032880 regulation of protein localization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034405 response to fluid shear stress
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042593 glucose homeostasis
GO:0042640 anagen
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045792 negative regulation of cell size
GO:0045861 negative regulation of proteolysis
GO:0045907 positive regulation of vasoconstriction
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046209 nitric oxide metabolic process
GO:0046326 positive regulation of glucose import
GO:0046329 negative regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0060644 mammary gland epithelial cell differentiation
GO:0060709 glycogen cell differentiation involved in embryonic placenta development
GO:0060716 labyrinthine layer blood vessel development
GO:0061024 membrane organization
GO:0070141 response to UV-A
GO:0071260 cellular response to mechanical stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071456 cellular response to hypoxia
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901653 cellular response to peptide
GO:1901976 regulation of cell cycle checkpoint
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0015630 microtubule cytoskeleton
GO:0036064 ciliary basal body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
Notch pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
TNFalpha pathway
Hedgehog pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
RANKL pathway
Leptin pathway
TSH pathway
TSLP pathway
FSH pathway
TWEAK pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
AKT-mediated inactivation of FOXO1A pathway
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
PI-3K cascade pathway
eNOS activation and regulation pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by Wnt pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by GPCR pathway
Downregulation of ERBB2:ERBB3 signaling pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Regulation of beta-cell development pathway
Metabolism of nitric oxide pathway
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
Signaling by SCF-KIT pathway
G-protein beta:gamma signalling pathway
deactivation of the beta-catenin transactivating complex pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
CD28 co-stimulation pathway
Integrin alphaIIb beta3 signaling pathway
AKT phosphorylates targets in the cytosol pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
Regulation of gene expression in beta cells pathway
Downstream signal transduction pathway
GPVI-mediated activation cascade pathway
TCF dependent signaling in response to WNT pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Platelet Aggregation (Plug Formation) pathway
Translocation of GLUT4 to the plasma membrane pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
CD28 dependent PI3K/Akt signaling pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Intrinsic Pathway for Apoptosis pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Signaling by ERBB2 pathway
Metabolism pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Costimulation by the CD28 family pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
CTLA4 inhibitory signaling pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
AKT phosphorylates targets in the nucleus pathway
Negative regulation of the PI3K/AKT network pathway
Gene Expression pathway
KSRP destabilizes mRNA pathway
Disease pathway
Activation of BAD and translocation to mitochondria pathway
Hemostasis pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
Membrane Trafficking pathway
eNOS activation pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Tight junction pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Adipocytokine signaling pathway pathway
Carbohydrate digestion and absorption pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Biocarta view]
Inhibition of cellular proliferation by gleevec [Biocarta view]
Corticosteroids and cardioprotection [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Actions of nitric oxide in the heart [Biocarta view]
Human cytomegalovirus and map kinase pathways [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Transcription factor creb and its extracellular signals [Biocarta view]
Telomeres telomerase cellular aging and immortality [Biocarta view]
Role of erbb2 in signal transduction and oncology [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Trka receptor signaling pathway [Biocarta view]
B cell survival pathway [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Regulation of eif-4e and p70s6 kinase [Biocarta view]
Il 4 signaling pathway [Biocarta view]
Apoptotic signaling in response to dna damage [Biocarta view]
Ras signaling pathway [Biocarta view]
Control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [Biocarta view]
Tumor suppressor arf inhibits ribosomal biogenesis [Biocarta view]
Hypoxia and p53 in the cardiovascular system [Biocarta view]
Mtor signaling pathway [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
Regulation of bad phosphorylation [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Skeletal muscle hypertrophy is regulated via akt-mtor pathway [Biocarta view]
Phosphoinositides and their downstream targets [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
Akt signaling pathway [Biocarta view]
Pten dependent cell cycle arrest and apoptosis [Biocarta view]
The igf-1 receptor and longevity [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Nephrin/Neph1 signaling in the kidney podocyte
FOXA2 and FOXA3 transcription factor networks
CD40/CD40L signaling
Nongenotropic Androgen signaling
Ceramide signaling pathway
TCR signaling in na´ve CD8+ T cells
Thromboxane A2 receptor signaling
E-cadherin signaling in the nascent adherens junction
IL8- and CXCR2-mediated signaling events
Caspase Cascade in Apoptosis
LPA receptor mediated events
Class I PI3K signaling events mediated by Akt
Aurora A signaling
CXCR4-mediated signaling events
Reelin signaling pathway
IL8- and CXCR1-mediated signaling events
Coregulation of Androgen receptor activity
TCR signaling in na´ve CD4+ T cells
Integrins in angiogenesis
VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by PTP1B
ErbB1 downstream signaling
mTOR signaling pathway
a6b1 and a6b4 Integrin signaling
IGF1 pathway
FoxO family signaling
p53 pathway
Integrin-linked kinase signaling
Glucocorticoid receptor regulatory network
p75(NTR)-mediated signaling
FGF signaling pathway
Endothelins
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
Retinoic acid receptors-mediated signaling
IL4-mediated signaling events
ErbB2/ErbB3 signaling events
S1P3 pathway
Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by VEGFR1 and VEGFR2
HIF-1-alpha transcription factor network
Plasma membrane estrogen receptor signaling
Signaling events mediated by the Hedgehog family
Hedgehog signaling events mediated by Gli proteins
CXCR3-mediated signaling events
Fc-epsilon receptor I signaling in mast cells
VEGFR1 specific signals
IL2 signaling events mediated by PI3K
IL6-mediated signaling events
Insulin Pathway
Insulin-mediated glucose transport
Regulation of Telomerase
IFN-gamma pathway
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.525622 Hs.690497 Hs.732482
RefSeq NM_001014431 NM_001014432 NM_005163 XM_005267401
HUGO
OMIM
CCDS CCDS9994
HPRD 01261
IMGT
EMBL
GenPept
RNA Seq Atlas