Version 5.4
Homo sapiens Gene: SLC4A7
Summary
InnateDB Gene IDBG-22923.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC4A7
Gene Name solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms NBC2; NBC3; NBCN1; SBC2; SLC4A6
Species Homo sapiens
Ensembl Gene ENSG00000033867
Encoded Proteins
IDBP-22925
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368776
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368789
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368838
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368857
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368863
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368868
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368875
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368879
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368886
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368898
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368900
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368903
solute carrier family 4, sodium bicarbonate cotransporter, member 7
IDBP-368905
solute carrier family 4, sodium bicarbonate cotransporter, member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:27372721-27484420
Strand Reverse strand
Band p24.1
Transcripts
ENST00000295736 ENSP00000295736
ENST00000425128 ENSP00000401949
ENST00000428386 ENSP00000416368
ENST00000419036 ENSP00000411031
ENST00000445684 ENSP00000406804
ENST00000454389 ENSP00000390394
ENST00000440156 ENSP00000414797
ENST00000437179 ENSP00000394252
ENST00000446700 ENSP00000406605
ENST00000455077 ENSP00000407382
ENST00000457377 ENSP00000408323
ENST00000438530 ENSP00000407304
ENST00000437266 ENSP00000409418
ENST00000428179 ENSP00000388703
ENST00000428005
ENST00000465487
ENST00000475120
ENST00000491211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005452 inorganic anion exchanger activity
GO:0008509 anion transmembrane transporter activity
GO:0008510 sodium:bicarbonate symporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006820 anion transport
GO:0015701 bicarbonate transport
GO:0021747 cochlear nucleus development
GO:0035725 sodium ion transmembrane transport
GO:0046666 retinal cell programmed cell death
GO:0055085 transmembrane transport
GO:0060117 auditory receptor cell development
GO:0061299 retina vasculature morphogenesis in camera-type eye
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0032420 stereocilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021733
View Gene Order
ENSBTAG00000018227
Not yet available
Pathways
NETPATH
REACTOME
REACT_19298
Bicarbonate transporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.250072 Hs.606925 Hs.623004
RefSeq NM_001258379 NM_001258380 NM_003615 XM_005265598 XM_005265599 XM_005265600 XM_005265601 XM_006713421
HUGO
OMIM
CCDS CCDS33721 CCDS58819 CCDS58820
HPRD 04521
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca