Homo sapiens Gene: SLC4A7
Summary
InnateDB Gene IDBG-22923.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC4A7
Gene Name solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms NBC2; NBC3; NBCN1; SBC2; SLC4A6;
Species Homo sapiens
Ensembl Gene ENSG00000033867
Encoded Proteins
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:27372721-27484420
Strand Reverse strand
Band p24.1
Transcripts
ENST00000295736 ENSP00000295736
ENST00000425128 ENSP00000401949
ENST00000428386 ENSP00000416368
ENST00000419036 ENSP00000411031
ENST00000445684 ENSP00000406804
ENST00000454389 ENSP00000390394
ENST00000440156 ENSP00000414797
ENST00000437179 ENSP00000394252
ENST00000446700 ENSP00000406605
ENST00000455077 ENSP00000407382
ENST00000457377 ENSP00000408323
ENST00000438530 ENSP00000407304
ENST00000437266 ENSP00000409418
ENST00000428179 ENSP00000388703
ENST00000428005
ENST00000465487
ENST00000475120
ENST00000491211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005452 inorganic anion exchanger activity
GO:0008509 anion transmembrane transporter activity
GO:0008510 sodium:bicarbonate symporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006820 anion transport
GO:0015701 bicarbonate transport
GO:0021747 cochlear nucleus development
GO:0035725 sodium ion transmembrane transport
GO:0046666 retinal cell programmed cell death
GO:0055085 transmembrane transport
GO:0060117 auditory receptor cell development
GO:0061299 retina vasculature morphogenesis in camera-type eye
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0032420 stereocilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Bicarbonate transporters pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y6M7
TrEMBL
UniProt Splice Variant
Entrez Gene 9497
UniGene Hs.250072 Hs.606925 Hs.623004
RefSeq NM_001258380 XM_005265601 NM_003615 NM_001258379 XM_005265600 XM_005265599 XM_005265598 XM_006713421
HUGO HGNC:11033
OMIM 603353
CCDS CCDS58819 CCDS33721 CCDS58820
HPRD 04521
IMGT
EMBL AB012130 AC099535 AF047033 AF053755 AF089726 CH471055 CR627428 EU499349 EU934246 EU934248 EU934249 EU934250 FJ178574 FJ178575 FJ178576 GU354307 GU354308 GU354309 GU354310
GenPept AAD38322 AAF21720 AAG16773 ACB47400 ACH61958 ACH61960 ACH61961 ACH61962 ACI24740 ACI24741 ACI24742 ADC32649 ADC32650 ADC32651 ADC32652 BAA25898 CAH10515 EAW64382
RNA Seq Atlas 9497