Homo sapiens Gene: HSPB1
Summary
InnateDB Gene IDBG-23058.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPB1
Gene Name heat shock 27kDa protein 1
Synonyms CMT2F; HEL-S-102; HMN2B; HS.76067; Hsp25; HSP27; HSP28; SRP27;
Species Homo sapiens
Ensembl Gene ENSG00000106211
Encoded Proteins
heat shock 27kDa protein 1
heat shock 27kDa protein 1
heat shock 27kDa protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:76302544-76304295
Strand Forward strand
Band q11.23
Transcripts
ENST00000248553 ENSP00000248553
ENST00000447574 ENSP00000414357
ENST00000429938 ENSP00000405285
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 372 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 372 [view]
Protein-Protein 372 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008426 protein kinase C inhibitor activity
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0043130 ubiquitin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001895 retina homeostasis
GO:0006446 regulation of translational initiation
GO:0006469 negative regulation of protein kinase activity
GO:0006928 cellular component movement
GO:0006986 response to unfolded protein
GO:0008219 cell death
GO:0009615 response to virus
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0032731 positive regulation of interleukin-1 beta production
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2001028 positive regulation of endothelial cell chemotaxis
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0000502 proteasome complex
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0030018 Z disc
GO:0043292 contractile fiber
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
TNFalpha pathway
IL3 pathway
IL6 pathway
Leptin pathway
FSH pathway
REACTOME
Signaling by VEGF pathway
Signal Transduction pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
VEGFA-VEGFR2 Pathway pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Gene Expression pathway
KEGG
MAPK signaling pathway pathway
VEGF signaling pathway pathway
Amoebiasis pathway
INOH
PID BIOCARTA
Downregulated of mta-3 in er-negative breast tumors [Biocarta view]
Stress induction of hsp regulation [Biocarta view]
P38 mapk signaling pathway [Biocarta view]
PID NCI
Signaling mediated by p38-alpha and p38-beta
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.726398
RefSeq NM_001540
HUGO
OMIM
CCDS CCDS5583
HPRD 09076
IMGT
EMBL
GenPept
RNA Seq Atlas