Version 5.4
Homo sapiens Gene: HSPB1
Summary
InnateDB Gene IDBG-23058.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPB1
Gene Name heat shock 27kDa protein 1
Synonyms CMT2F; HEL-S-102; HMN2B; HS.76067; Hsp25; HSP27; HSP28; SRP27
Species Homo sapiens
Ensembl Gene ENSG00000106211
Encoded Proteins
IDBP-23060
heat shock 27kDa protein 1
IDBP-379744
heat shock 27kDa protein 1
IDBP-379746
heat shock 27kDa protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:76302544-76304295
Strand Forward strand
Band q11.23
Transcripts
ENST00000248553 ENSP00000248553
ENST00000447574 ENSP00000414357
ENST00000429938 ENSP00000405285
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 372 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 372 [view]
Protein-Protein 372 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008426 protein kinase C inhibitor activity
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0043130 ubiquitin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001895 retina homeostasis
GO:0006446 regulation of translational initiation
GO:0006469 negative regulation of protein kinase activity
GO:0006928 cellular component movement
GO:0006986 response to unfolded protein
GO:0008219 cell death
GO:0009615 response to virus
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0032731 positive regulation of interleukin-1 beta production
GO:0035556 intracellular signal transduction
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2001028 positive regulation of endothelial cell chemotaxis
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0000502 proteasome complex
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0030018 Z disc
GO:0043292 contractile fiber
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004951
View Gene Order
ENSBTAG00000011969
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_9
TNFalpha pathway
NetPath_15
IL3 pathway
NetPath_18
IL6 pathway
NetPath_22
Leptin pathway
NetPath_25
FSH pathway
REACTOME
REACT_25325
AUF1 (hnRNP D0) destabilizes mRNA pathway
REACT_12529
Signaling by VEGF pathway
REACT_111102
Signal Transduction pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa05146
Amoebiasis pathway
INOH
PID NCI
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
p38_mk2pathway
p38 signaling mediated by MAPKAP kinases
Cross-References
SwissProt P04792
TrEMBL C9J3N8 F8WE04 V9HW43
UniProt Splice Variant
Entrez Gene 3315
UniGene Hs.726398
RefSeq NM_001540
HUGO HGNC:5246
OMIM 602195
CCDS CCDS5583
HPRD
IMGT
EMBL AB020027 AC006388 AK311894 BC000510 BC012292 BC012768 BC014920 BC073768 BT019888 CH471220 CR407614 CR536489 DQ379985 FJ224323 L39370 S74571 U90906 X16477 X54079 Z23090
GenPept AAA62175 AAB20722 AAB51056 AAH00510 AAH12292 AAH12768 AAH14920 AAH73768 AAV38691 ABC88475 ACI46015 BAB17232 BAG34835 CAA34498 CAA38016 CAA80636 CAG28542 CAG38728 EAW71803
RNA Seq Atlas 3315

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca