Version 5.4
Homo sapiens Gene: ASGR1
Summary
InnateDB Gene IDBG-23366.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASGR1
Gene Name asialoglycoprotein receptor 1
Synonyms ASGPR; ASGPR1; CLEC4H1; HL-1
Species Homo sapiens
Ensembl Gene ENSG00000141505
Encoded Proteins
IDBP-23368
asialoglycoprotein receptor 1
IDBP-23370
asialoglycoprotein receptor 1
IDBP-761912
IDBP-761775
IDBP-764073
IDBP-758815
IDBP-758858
IDBP-809424
asialoglycoprotein receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7173431-7179564
Strand Reverse strand
Band p13.1
Transcripts
ENST00000380920 ENSP00000370307
ENST00000269299 ENSP00000269299
ENST00000573596
ENST00000572879 ENSP00000458530
ENST00000570576 ENSP00000458803
ENST00000574330 ENSP00000467511
ENST00000574388 ENSP00000459169
ENST00000573083 ENSP00000459896
ENST00000619926 ENSP00000481182
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004873 asialoglycoprotein receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0031668 cellular response to extracellular stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020884
View Gene Order
ENSBTAG00000012071
Not yet available
Cross-References
SwissProt
TrEMBL I3L2S9
UniProt Splice Variant
Entrez Gene 432
UniGene Hs.12056 Hs.731669
RefSeq NM_001197216 NM_001671
HUGO HGNC:742
OMIM 108360
CCDS CCDS11089 CCDS56017
HPRD 00151
IMGT
EMBL AC120057
GenPept
RNA Seq Atlas 432

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca