Homo sapiens Gene: FIS1
Summary
InnateDB Gene IDBG-234267.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FIS1
Gene Name fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000214253
Encoded Proteins
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:101239458-101252316
Strand Reverse strand
Band q22.1
Transcripts
ENST00000223136 ENSP00000223136
ENST00000449367 ENSP00000411442
ENST00000442303 ENSP00000395964
ENST00000435848 ENSP00000413500
ENST00000482199
ENST00000474120 ENSP00000442056
ENST00000463406
ENST00000473527 ENSP00000444771
ENST00000480497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0000266 mitochondrial fission
GO:0000422 mitochondrion degradation
GO:0001836 release of cytochrome c from mitochondria
GO:0006626 protein targeting to mitochondrion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008053 mitochondrial fusion
GO:0010821 regulation of mitochondrion organization
GO:0016559 peroxisome fission
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0051260 protein homooligomerization
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0070584 mitochondrion morphogenesis
GO:0090141 positive regulation of mitochondrial fission
GO:0090314 positive regulation of protein targeting to membrane
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005779 integral component of peroxisomal membrane
GO:0016020 membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0043234 protein complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL F8WD11
UniProt Splice Variant
Entrez Gene 51024
UniGene
RefSeq NM_016068
HUGO HGNC:21689
OMIM 609003
CCDS CCDS43626
HPRD 12352
IMGT
EMBL AC006329
GenPept
RNA Seq Atlas 51024