InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DLG4

Summary

InnateDB Gene

IDBG-23446.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLG4

Gene Name

discs, large homolog 4 (Drosophila)

Synonyms

PSD95; SAP-90; SAP90

Species

Homo sapiens

Ensembl Gene

ENSG00000132535

Encoded Proteins

IDBP-23452

discs, large homolog 4 (Drosophila)

IDBP-230439

discs, large homolog 4 (Drosophila)

IDBP-230441

discs, large homolog 4 (Drosophila)

IDBP-364997

discs, large homolog 4 (Drosophila)

IDBP-364999

discs, large homolog 4 (Drosophila)

IDBP-764715

IDBP-760171

IDBP-762564

IDBP-763322

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:7189890-7219702

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000302955	ENSP00000307471
ENST00000399510	ENSP00000382428
ENST00000399506	ENSP00000382425
ENST00000451807	ENSP00000407918
ENST00000447163	ENSP00000388122
ENST00000489885
ENST00000491753	ENSP00000467897
ENST00000485100	ENSP00000460625
ENST00000486626	ENSP00000465720
ENST00000493294	ENSP00000465789

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	136 [view]
Protein-Protein	133 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019903	protein phosphatase binding
GO:0030165	PDZ domain binding
GO:0031697	beta-1 adrenergic receptor binding
GO:0031748	D1 dopamine receptor binding
GO:0031812	P2Y1 nucleotide receptor binding
GO:0032403	protein complex binding
GO:0033130	acetylcholine receptor binding
GO:0035254	glutamate receptor binding
GO:0035255	ionotropic glutamate receptor binding
GO:0097110	scaffold protein binding

Biological Process

GO:0002091	negative regulation of receptor internalization
GO:0006461	protein complex assembly
GO:0007165	signal transduction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007612	learning
GO:0016188	synaptic vesicle maturation
GO:0035176	social behavior
GO:0035418	protein localization to synapse
GO:0035641	locomotory exploration behavior
GO:0045184	establishment of protein localization
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0050806	positive regulation of synaptic transmission
GO:0050885	neuromuscular process controlling balance
GO:0060997	dendritic spine morphogenesis
GO:0071625	vocalization behavior
GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097120	receptor localization to synapse
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential
GO:2000821	regulation of grooming behavior

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0008328	ionotropic glutamate receptor complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0030666	endocytic vesicle membrane
GO:0030863	cortical cytoskeleton
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0032839	dendrite cytoplasm
GO:0043197	dendritic spine
GO:0044224	juxtaparanode region of axon
GO:0044300	cerebellar mossy fiber
GO:0044306	neuron projection terminus
GO:0044309	neuron spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0097481	neuronal postsynaptic density