Version 5.4
Homo sapiens Gene: AP1G2
Summary
InnateDB Gene IDBG-236004.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP1G2
Gene Name adaptor-related protein complex 1, gamma 2 subunit
Synonyms G2AD
Species Homo sapiens
Ensembl Gene ENSG00000213983
Encoded Proteins
IDBP-3384
adaptor-related protein complex 1, gamma 2 subunit
IDBP-236006
adaptor-related protein complex 1, gamma 2 subunit
IDBP-597930
adaptor-related protein complex 1, gamma 2 subunit
IDBP-598369
adaptor-related protein complex 1, gamma 2 subunit
IDBP-601471
adaptor-related protein complex 1, gamma 2 subunit
IDBP-599352
adaptor-related protein complex 1, gamma 2 subunit
IDBP-603122
adaptor-related protein complex 1, gamma 2 subunit
IDBP-602610
adaptor-related protein complex 1, gamma 2 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. There are two alternatively spliced transcript variants of this gene encoding the same protein. [provided by RefSeq, Jul 2008]
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. Several alternatively spliced transcript variants of this gene exist, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:23559565-23568070
Strand Reverse strand
Band q11.2
Transcripts
ENST00000308724 ENSP00000312442
ENST00000397120 ENSP00000380309
ENST00000460049
ENST00000465445
ENST00000554892
ENST00000554554
ENST00000557391
ENST00000554477 ENSP00000450805
ENST00000555510
ENST00000556966
ENST00000554982
ENST00000555118
ENST00000557132
ENST00000557162 ENSP00000450588
ENST00000555789
ENST00000555974
ENST00000556741
ENST00000554977
ENST00000556152
ENST00000556277
ENST00000553629
ENST00000556743
ENST00000556943 ENSP00000450888
ENST00000555896
ENST00000557619
ENST00000557482
ENST00000554312
ENST00000557189 ENSP00000452153
ENST00000553756 ENSP00000451343
ENST00000554069
ENST00000556843 ENSP00000451504
ENST00000553685
ENST00000554816
ENST00000535852
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
Biological Process
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005798 Golgi-associated vesicle
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030121 AP-1 adaptor complex
GO:0030131 clathrin adaptor complex
GO:0030133 transport vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040701
View Gene Order
ENSBTAG00000007099
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.343244 Hs.569375 Hs.740123
RefSeq NM_001282474 NM_001282475 NM_003917 XM_005268171 XM_005268172 XM_005268173 XM_005268180
HUGO
OMIM
CCDS CCDS9602
HPRD 04638
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca