InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSNK1E

Summary

InnateDB Gene

IDBG-236645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSNK1E

Gene Name

casein kinase 1, epsilon

Synonyms

CKIepsilon; HCKIE

Species

Homo sapiens

Ensembl Gene

ENSG00000213923

Encoded Proteins

IDBP-7443

casein kinase 1, epsilon

IDBP-376585

casein kinase 1, epsilon

IDBP-228807

casein kinase 1, epsilon

IDBP-236647

casein kinase 1, epsilon

IDBP-293614

casein kinase 1, epsilon

IDBP-293616

casein kinase 1, epsilon

IDBP-376586

casein kinase 1, epsilon

IDBP-376595

casein kinase 1, epsilon

IDBP-376600

casein kinase 1, epsilon

IDBP-376605

casein kinase 1, epsilon

IDBP-376606

casein kinase 1, epsilon

IDBP-376609

casein kinase 1, epsilon

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:38290691-38398522

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000359867	ENSP00000352929
ENST00000366216	ENSP00000400494
ENST00000400206	ENSP00000383067
ENST00000396832	ENSP00000380044
ENST00000403904	ENSP00000384074
ENST00000405675	ENSP00000384426
ENST00000431632	ENSP00000403610
ENST00000431611	ENSP00000412194
ENST00000413574	ENSP00000407235
ENST00000442216	ENSP00000397460
ENST00000451964	ENSP00000403057
ENST00000430335	ENSP00000412335
ENST00000495232
ENST00000494610
ENST00000498529
ENST00000612795

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	129 [view]
Protein-Protein	122 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006281	DNA repair
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0030178	negative regulation of Wnt signaling pathway
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032922	circadian regulation of gene expression
GO:0034613	cellular protein localization
GO:0042752	regulation of circadian rhythm
GO:0090263	positive regulation of canonical Wnt signaling pathway