Homo sapiens Gene: CSNK1E
Summary
InnateDB Gene IDBG-236645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSNK1E
Gene Name casein kinase 1, epsilon
Synonyms CKIepsilon; HCKIE;
Species Homo sapiens
Ensembl Gene ENSG00000213923
Encoded Proteins
casein kinase 1, epsilon
casein kinase 1, epsilon
casein kinase 1, epsilon
casein kinase 1, epsilon
casein kinase 1, epsilon
casein kinase 1, epsilon
casein kinase 1, epsilon
casein kinase 1, epsilon
casein kinase 1, epsilon
casein kinase 1, epsilon
casein kinase 1, epsilon
casein kinase 1, epsilon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:38290691-38398522
Strand Reverse strand
Band q13.1
Transcripts
ENST00000359867 ENSP00000352929
ENST00000366216 ENSP00000400494
ENST00000400206 ENSP00000383067
ENST00000396832 ENSP00000380044
ENST00000403904 ENSP00000384074
ENST00000405675 ENSP00000384426
ENST00000431632 ENSP00000403610
ENST00000431611 ENSP00000412194
ENST00000413574 ENSP00000407235
ENST00000442216 ENSP00000397460
ENST00000451964 ENSP00000403057
ENST00000430335 ENSP00000412335
ENST00000495232
ENST00000494610
ENST00000498529
ENST00000612795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 129 [view]
Protein-Protein 122 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0030178 negative regulation of Wnt signaling pathway
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032922 circadian regulation of gene expression
GO:0034613 cellular protein localization
GO:0042752 regulation of circadian rhythm
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
Wnt pathway
REACTOME
WNT mediated activation of DVL pathway
Circadian Clock pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Loss of Nlp from mitotic centrosomes pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Signal Transduction pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
Centrosome maturation pathway
TCF dependent signaling in response to WNT pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Mitotic G2-G2/M phases pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Circadian rhythm pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Wnt signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Circadian rhythm pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 1454
UniGene Hs.474833 Hs.621730 Hs.732200
RefSeq NM_001894 NM_001289912 NM_152221
HUGO HGNC:2453
OMIM 600863
CCDS CCDS13970
HPRD 02919
IMGT
EMBL
GenPept
RNA Seq Atlas 102800317 1454