Homo sapiens Gene: GNAI1
Summary
InnateDB Gene IDBG-23949.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNAI1
Gene Name guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Synonyms Gi;
Species Homo sapiens
Ensembl Gene ENSG00000127955
Encoded Proteins
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:80133955-80219402
Strand Forward strand
Band q21.11
Transcripts
ENST00000351004 ENSP00000343027
ENST00000442586 ENSP00000391439
ENST00000418742 ENSP00000389435
ENST00000457358 ENSP00000410572
ENST00000447650 ENSP00000388347
ENST00000490206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
Experimentally validated
Total 62 [view]
Protein-Protein 62 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031821 G-protein coupled serotonin receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0043434 response to peptide hormone
GO:0051301 cell division
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005813 centrosome
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0030496 midbody
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSH pathway
REACTOME
G alpha (s) signalling events pathway
Integration of energy metabolism pathway
ADP signalling through P2Y purinoceptor 12 pathway
Adenylate cyclase inhibitory pathway pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Neuronal System pathway
Signaling by GPCR pathway
PLC beta mediated events pathway
GABA receptor activation pathway
Platelet activation, signaling and aggregation pathway
Opioid Signalling pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
G-protein activation pathway
G-protein mediated events pathway
G alpha (z) signalling events pathway
GABA B receptor activation pathway
Transmission across Chemical Synapses pathway
Regulation of insulin secretion pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inhibition of adenylate cyclase pathway pathway
Signal amplification pathway
Hemostasis pathway
KEGG
Chemokine signaling pathway pathway
Axon guidance pathway
Tight junction pathway
Gap junction pathway
Leukocyte transendothelial migration pathway
Long-term depression pathway
Progesterone-mediated oocyte maturation pathway
Melanogenesis pathway
Gastric acid secretion pathway
Parkinson's disease pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
INOH
GPCR signaling pathway
PID BIOCARTA
Signaling pathway from g-protein families [Biocarta view]
Aspirin blocks signaling pathway involved in platelet activation [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Cxcr4 signaling pathway [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
How progesterone initiates the oocyte maturation [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
PID NCI
SHP2 signaling
Cross-References
SwissProt
TrEMBL C9J2Z2
UniProt Splice Variant
Entrez Gene 2770
UniGene Hs.134587 Hs.604217
RefSeq NM_001256414 NM_002069
HUGO HGNC:4384
OMIM 139310
CCDS CCDS5595 CCDS59061
HPRD 00756
IMGT
EMBL AC004159 AC080066
GenPept
RNA Seq Atlas 2770