InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNAI1

Summary

InnateDB Gene

IDBG-23949.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNAI1

Gene Name

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000127955

Encoded Proteins

IDBP-23953

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

IDBP-380256

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

IDBP-380266

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

IDBP-380268

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

IDBP-380269

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:80133955-80219402

Strand

Forward strand

Band

q21.11

Transcripts

ENST00000351004	ENSP00000343027
ENST00000442586	ENSP00000391439
ENST00000418742	ENSP00000389435
ENST00000457358	ENSP00000410572
ENST00000447650	ENSP00000388347
ENST00000490206

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.

Experimentally validated
Total	62 [view]
Protein-Protein	62 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031821	G-protein coupled serotonin receptor binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0043434	response to peptide hormone
GO:0051301	cell division

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005813	centrosome
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0030496	midbody
GO:0070062	extracellular vesicular exosome