Homo sapiens Gene: LAT
Summary
InnateDB Gene IDBG-239499.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAT
Gene Name linker for activation of T cells
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000213658
Encoded Proteins
linker for activation of T cells
linker for activation of T cells
linker for activation of T cells
linker for activation of T cells
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
LAT dephosphorylation in human platelets is integrin-mediated and involves PTPN1 protein tyrosine phosphatase and both PTPN1 activation and LAT dephosphorylation processes were involved in the control of irreversible platelet aggregation upon FcgammaRIIa stimulation.
Entrez Gene
Summary The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:28984826-28990783
Strand Forward strand
Band p11.2
Transcripts
ENST00000360872 ENSP00000354119
ENST00000354453
ENST00000395461 ENSP00000378845
ENST00000395456 ENSP00000378841
ENST00000454369 ENSP00000398793
ENST00000564277 ENSP00000457036
ENST00000563964
ENST00000570232 ENSP00000455728
ENST00000562701 ENSP00000454793
ENST00000562472
ENST00000566177 ENSP00000456761
ENST00000568440
ENST00000566270
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 66 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0002260 lymphocyte homeostasis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007596 blood coagulation
GO:0009967 positive regulation of signal transduction
GO:0010467 gene expression
GO:0019722 calcium-mediated signaling
GO:0030168 platelet activation
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042110 T cell activation
GO:0043303 mast cell degranulation
GO:0045087 innate immune response (InnateDB)
GO:0048872 homeostasis of number of cells
GO:0050852 T cell receptor signaling pathway
GO:0050863 regulation of T cell activation
Cellular Component
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042629 mast cell granule
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
KitReceptor pathway
TCR pathway
REACTOME
TCR signaling pathway
Platelet activation, signaling and aggregation pathway
Adaptive Immune System pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Generation of second messenger molecules pathway
Hemostasis pathway
KEGG
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
Ras-independent pathway in nk cell-mediated cytotoxicity [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
PID NCI
TCR signaling in na´ve CD8+ T cells
TCR signaling in na´ve CD4+ T cells
Signaling events mediated by PTP1B
JNK signaling in the CD4+ TCR pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt O43561
TrEMBL
UniProt Splice Variant
Entrez Gene 27040
UniGene
RefSeq NM_014387 NM_001014989 NM_001014987 NM_001014988
HUGO HGNC:18874
OMIM 602354
CCDS CCDS45455 CCDS10647 CCDS53999 CCDS32425
HPRD 03832
IMGT
EMBL AC109460 AF036905 AF036906 AJ223280 BC011563 CH471267 FN432832
GenPept AAC39636 AAC39637 AAH11563 CAA11218 CBA11533 EAW52027 EAW52028
RNA Seq Atlas 27040