InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CD36

Summary

InnateDB Gene

IDBG-24023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD36

Gene Name

CD36 molecule (thrombospondin receptor)

Synonyms

BDPLT10; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3

Species

Homo sapiens

Ensembl Gene

ENSG00000135218

Encoded Proteins

IDBP-24025

CD36 molecule (thrombospondin receptor)

IDBP-240875

CD36 molecule (thrombospondin receptor)

IDBP-380335

CD36 molecule (thrombospondin receptor)

IDBP-380339

CD36 molecule (thrombospondin receptor)

IDBP-380341

CD36 molecule (thrombospondin receptor)

IDBP-380343

CD36 molecule (thrombospondin receptor)

IDBP-380345

CD36 molecule (thrombospondin receptor)

IDBP-380352

CD36 molecule (thrombospondin receptor)

IDBP-380353

CD36 molecule (thrombospondin receptor)

IDBP-380356

CD36 molecule (thrombospondin receptor)

IDBP-380358

CD36 molecule (thrombospondin receptor)

IDBP-380359

CD36 molecule (thrombospondin receptor)

IDBP-380361

CD36 molecule (thrombospondin receptor)

IDBP-591881

CD36 molecule (thrombospondin receptor)

IDBP-584036

CD36 molecule (thrombospondin receptor)

IDBP-598402

CD36 molecule (thrombospondin receptor)

IDBP-596061

CD36 molecule (thrombospondin receptor)

IDBP-593577

CD36 molecule (thrombospondin receptor)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19237602

CD36 mediates host defence against Cryptococcus neoformans and Candida albicans through cytokine production.

PMID 19847289

CD36 ectodomain binds negatively charged diacylglycerol ligands and CD36, along with CD14, has a non-redundant role for loading ligands onto TLR2 in the plasma-membrane.

PMID 15690042

CD36 is a selective and non-redundant sensor of microbial diacylglycerides that signal via the TLR2/6 heterodimer.

PMID 20037584

CD36-TLR4-TLR6 activation is a common molecular mechanism by which atherogenic lipids and amyloid-beta stimulate sterile inflammation.

InnateDB Annotation from Orthologs

Summary

PMID 24257313

[Mus musculus] MSR1 and Cd36 share several ligands and are involved in largely overlapping physiological and pathological processes, but they differ significantly in their effects on proinflammatory and immunoregulatory functions of macrophages.

Entrez Gene

Summary

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:80369575-80679277

Strand

Forward strand

Band

q21.11

Transcripts

ENST00000309881	ENSP00000308165
ENST00000394788	ENSP00000378268
ENST00000435819	ENSP00000399421
ENST00000438020	ENSP00000410371
ENST00000436384	ENSP00000398760
ENST00000428497	ENSP00000409762
ENST00000447544	ENSP00000415743
ENST00000441109
ENST00000432207	ENSP00000411411
ENST00000426978	ENSP00000416388
ENST00000413265	ENSP00000407690
ENST00000433696	ENSP00000401863
ENST00000419819	ENSP00000392298
ENST00000441034	ENSP00000396258
ENST00000480599
ENST00000478292
ENST00000482059	ENSP00000433659
ENST00000464213
ENST00000488048	ENSP00000435698
ENST00000534394	ENSP00000431296
ENST00000526804
ENST00000538969	ENSP00000439543
ENST00000544133	ENSP00000441956

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	20 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005515	protein binding
GO:0008035	high-density lipoprotein particle binding
GO:0008289	lipid binding
GO:0030169	low-density lipoprotein particle binding
GO:0050431	transforming growth factor beta binding
GO:0070053	thrombospondin receptor activity
GO:0070892	lipoteichoic acid receptor activity
GO:0071813	lipoprotein particle binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002221	pattern recognition receptor signaling pathway
GO:0002224	toll-like receptor signaling pathway
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002576	platelet degranulation
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006629	lipid metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0006910	phagocytosis, recognition
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007263	nitric oxide mediated signal transduction
GO:0007596	blood coagulation
GO:0010629	negative regulation of gene expression
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010886	positive regulation of cholesterol storage
GO:0015911	plasma membrane long-chain fatty acid transport
GO:0019915	lipid storage
GO:0019934	cGMP-mediated signaling
GO:0030168	platelet activation
GO:0030194	positive regulation of blood coagulation
GO:0030301	cholesterol transport
GO:0032735	positive regulation of interleukin-12 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034381	plasma lipoprotein particle clearance
GO:0034383	low-density lipoprotein particle clearance
GO:0035634	response to stilbenoid
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042953	lipoprotein transport
GO:0042992	negative regulation of transcription factor import into nucleus
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043277	apoptotic cell clearance
GO:0043410	positive regulation of MAPK cascade
GO:0044130	negative regulation of growth of symbiont in host
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0044539	long-chain fatty acid import
GO:0045087	innate immune response (InnateDB)
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050830	defense response to Gram-positive bacterium
GO:0055096	low-density lipoprotein particle mediated signaling
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0060907	positive regulation of macrophage cytokine production
GO:0071221	cellular response to bacterial lipopeptide
GO:0071222	cellular response to lipopolysaccharide
GO:0071223	cellular response to lipoteichoic acid
GO:0071447	cellular response to hydroperoxide
GO:2000121	regulation of removal of superoxide radicals
GO:2000334	positive regulation of blood microparticle formation
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030666	endocytic vesicle membrane
GO:0031092	platelet alpha granule membrane
GO:0045121	membrane raft
GO:0045335	phagocytic vesicle