Version 5.4
Homo sapiens Gene: TRIM23
Summary
InnateDB Gene IDBG-24045.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM23
Gene Name tripartite motif containing 23
Synonyms ARD1; ARFD1; RNF46
Species Homo sapiens
Ensembl Gene ENSG00000113595
Encoded Proteins
IDBP-24049
tripartite motif containing 23
IDBP-24051
tripartite motif containing 23
IDBP-24053
tripartite motif containing 23
IDBP-481099
tripartite motif containing 23
IDBP-484285
tripartite motif containing 23
IDBP-474586
tripartite motif containing 23
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20724660
TRIM23 mediates K(lys)-27-ubiquitin conjugation to IKBKG (NEMO) which is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses.
PMID 23438823
TRIM23 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:65589680-65625975
Strand Reverse strand
Band q12.3
Transcripts
ENST00000231524 ENSP00000231524
ENST00000274327 ENSP00000274327
ENST00000381018 ENSP00000370406
ENST00000508808
ENST00000506400 ENSP00000427103
ENST00000505205 ENSP00000424044
ENST00000513794 ENSP00000422144
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.
Experimentally validated
Total 157 [view]
Protein-Protein 155 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008047 enzyme activator activity
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019001 guanyl nucleotide binding
GO:0019003 GDP binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0043085 positive regulation of catalytic activity
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021712
View Gene Order
ENSBTAG00000009519
Not yet available
Cross-References
SwissProt
TrEMBL D6RD22
UniProt Splice Variant
Entrez Gene 373
UniGene Hs.792
RefSeq NM_001656 NM_033227 NM_033228 XM_005248497
HUGO HGNC:660
OMIM 601747
CCDS CCDS3986 CCDS3987 CCDS43322
HPRD 03449
IMGT
EMBL AC008560
GenPept
RNA Seq Atlas 373

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca