Homo sapiens Gene: DCLK1 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-24120.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | DCLK1 | ||||||||||||||||||||||||||
Gene Name | doublecortin-like kinase 1 | ||||||||||||||||||||||||||
Synonyms | CL1; CLICK1; DCAMKL1; DCDC3A; DCLK | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Gene | ENSG00000133083 | ||||||||||||||||||||||||||
Encoded Proteins |
doublecortin-like kinase 1
doublecortin-like kinase 1
doublecortin-like kinase 1
doublecortin-like kinase 1
doublecortin-like kinase 1
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 13:35768652-36131306 | ||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||
Band | q13.3 | ||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | Q5VZY9 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 9201 | ||||||||||||||||||||||||||
UniGene | Hs.507755 Hs.605020 Hs.607774 | ||||||||||||||||||||||||||
RefSeq | NM_001195415 NM_001195416 NM_004734 XM_005266592 XM_006719893 | ||||||||||||||||||||||||||
HUGO | HGNC:2700 | ||||||||||||||||||||||||||
OMIM | 604742 | ||||||||||||||||||||||||||
CCDS | CCDS55895 CCDS73561 CCDS9354 | ||||||||||||||||||||||||||
HPRD | 09202 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AL157694 AL157760 AL160392 AL390029 | ||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | 9201 | ||||||||||||||||||||||||||