Homo sapiens Gene: HGF
Summary
InnateDB Gene IDBG-24150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HGF
Gene Name hepatocyte growth factor (hepapoietin A; scatter factor)
Synonyms DFNB39; F-TCF; HGFB; HPTA; SF;
Species Homo sapiens
Ensembl Gene ENSG00000019991
Encoded Proteins
hepatocyte growth factor (hepapoietin A; scatter factor)
hepatocyte growth factor (hepapoietin A; scatter factor)
hepatocyte growth factor (hepapoietin A; scatter factor)
hepatocyte growth factor (hepapoietin A; scatter factor)
hepatocyte growth factor (hepapoietin A; scatter factor)
hepatocyte growth factor (hepapoietin A; scatter factor)
hepatocyte growth factor (hepapoietin A; scatter factor)
hepatocyte growth factor (hepapoietin A; scatter factor)
hepatocyte growth factor (hepapoietin A; scatter factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:81699006-81770438
Strand Reverse strand
Band q21.11
Transcripts
ENST00000222390 ENSP00000222390
ENST00000354224 ENSP00000346164
ENST00000457544 ENSP00000391238
ENST00000444829 ENSP00000389854
ENST00000453411 ENSP00000408270
ENST00000423064 ENSP00000413829
ENST00000453018 ENSP00000395468
ENST00000412881 ENSP00000396307
ENST00000421558 ENSP00000388592
ENST00000465234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0000902 cell morphogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0002576 platelet degranulation
GO:0006508 proteolysis
GO:0007067 mitotic nuclear division
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168 platelet activation
GO:0030212 hyaluronan metabolic process
GO:0030335 positive regulation of cell migration
GO:0031100 organ regeneration
GO:0031643 positive regulation of myelination
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0051450 myoblast proliferation
GO:0060326 cell chemotaxis
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0070572 positive regulation of neuron projection regeneration
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000573 positive regulation of DNA biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031093 platelet alpha granule lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Immune System pathway
Signaling by Interleukins pathway
Response to elevated platelet cytosolic Ca2+ pathway
Interleukin-7 signaling pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Focal adhesion pathway
Malaria pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Melanoma pathway
INOH
GPCR signaling pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Direct p53 effectors
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
FGF signaling pathway
Signaling events mediated by TCPTP
Stabilization and expansion of the E-cadherin adherens junction
Syndecan-1-mediated signaling events
Arf6 signaling events
Cross-References
SwissProt
TrEMBL C9JS80
UniProt Splice Variant
Entrez Gene 3082
UniGene Hs.396530 Hs.561679 Hs.611986 Hs.737588
RefSeq NM_000601 NM_001010932 NM_001010931 NM_001010933 NM_001010934 XM_006715956
HUGO HGNC:4893
OMIM 142409
CCDS CCDS5597 CCDS47626 CCDS47627 CCDS47628 CCDS47629
HPRD 00799
IMGT
EMBL AC004960
GenPept
RNA Seq Atlas 3082