Homo sapiens Gene: COPS5
Summary
InnateDB Gene IDBG-24191.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPS5
Gene Name COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
Synonyms CSN5; JAB1; MOV-34; SGN5;
Species Homo sapiens
Ensembl Gene ENSG00000121022
Encoded Proteins
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
COPS5 is required for the activation of pro-inflammatory kinases, p38 and ErK, and the down-regulation of NFE2L2 gene targets. Mice with Cops5 deficiency have lower mortality in polymicrobial sepsis. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cops5 is required for activation of pro-inflammatory kinases, p38 and ErK, and the down-regulation of Nfe2l2 gene targets. Mice with Cops5 deficiency have lower mortality in polymicrobial sepsis.
Entrez Gene
Summary The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:67043079-67083783
Strand Reverse strand
Band q13.1
Transcripts
ENST00000357849 ENSP00000350512
ENST00000523086
ENST00000521509
ENST00000517736 ENSP00000429774
ENST00000521386
ENST00000518374 ENSP00000427869
ENST00000523890 ENSP00000427997
ENST00000518747 ENSP00000428586
ENST00000517793
ENST00000517406 ENSP00000428124
ENST00000519963
ENST00000519057
ENST00000518768
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 856 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 856 [view]
Protein-Protein 856 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003743 translation initiation factor activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0000338 protein deneddylation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006412 translation
GO:0006413 translational initiation
GO:0006508 proteolysis
GO:0010388 cullin deneddylation
GO:0016579 protein deubiquitination
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046328 regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:1990182 exosomal secretion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0008021 synaptic vesicle
GO:0008180 COP9 signalosome
GO:0030054 cell junction
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
Hypoxia-inducible factor in the cardivascular system [Biocarta view]
Erythropoietin mediated neuroprotection through nf-kb [Biocarta view]
PID NCI
AP-1 transcription factor network
HIF-1-alpha transcription factor network
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt Q92905
TrEMBL A0A024R7W9 E5RFS1 E5RG35 E5RHF2 E5RHH5 E5RK55
UniProt Splice Variant
Entrez Gene 10987
UniGene Hs.491912 Hs.598985
RefSeq NM_006837
HUGO HGNC:2240
OMIM 604850
CCDS CCDS6198
HPRD
IMGT
EMBL AC109335 AC110998 AY078082 BC001187 BC001859 BC007272 BX648542 CH471068 CR541678 U65928 U70734
GenPept AAB16847 AAD03468 AAH01187 AAH01859 AAH07272 AAL82571 CAG46479 CAH10375 EAW86928 EAW86929 EAW86931
RNA Seq Atlas 10987