Version 5.4
Homo sapiens Gene: NLN
Summary
InnateDB Gene IDBG-24328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLN
Gene Name neurolysin (metallopeptidase M3 family)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000123213
Encoded Proteins
IDBP-24330
neurolysin (metallopeptidase M3 family)
IDBP-474497
neurolysin (metallopeptidase M3 family)
IDBP-474416
neurolysin (metallopeptidase M3 family)
IDBP-480307
neurolysin (metallopeptidase M3 family)
IDBP-475956
neurolysin (metallopeptidase M3 family)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:65722196-65871725
Strand Forward strand
Band q12.3
Transcripts
ENST00000380985 ENSP00000370372
ENST00000502464 ENSP00000423214
ENST00000514991 ENSP00000422822
ENST00000506539
ENST00000506799
ENST00000506677
ENST00000511299 ENSP00000427417
ENST00000509935 ENSP00000426959
ENST00000507201
ENST00000515595
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021710
View Gene Order
ENSBTAG00000016903
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04614
Renin-angiotensin system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.247460 Hs.611336
RefSeq NM_020726 XM_006714661
HUGO
OMIM
CCDS CCDS3989
HPRD 07495
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca