Homo sapiens Gene: EREG
Summary
InnateDB Gene IDBG-24370.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EREG
Gene Name epiregulin
Synonyms ER;
Species Homo sapiens
Ensembl Gene ENSG00000124882
Encoded Proteins
epiregulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:74365143-74388751
Strand Forward strand
Band q13.3
Transcripts
ENST00000244869 ENSP00000244869
ENST00000507603
ENST00000503689
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001525 angiogenesis
GO:0001550 ovarian cumulus expansion
GO:0001556 oocyte maturation
GO:0001819 positive regulation of cytokine production
GO:0007143 female meiotic division
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009299 mRNA transcription
GO:0009653 anatomical structure morphogenesis
GO:0009887 organ morphogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0030216 keratinocyte differentiation
GO:0030728 ovulation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042108 positive regulation of cytokine biosynthetic process
GO:0042327 positive regulation of phosphorylation
GO:0042700 luteinizing hormone signaling pathway
GO:0043434 response to peptide hormone
GO:0043616 keratinocyte proliferation
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0045740 positive regulation of DNA replication
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045840 positive regulation of mitosis
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048160 primary follicle stage
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051151 negative regulation of smooth muscle cell differentiation
GO:0051781 positive regulation of cell division
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
GRB2 events in ERBB2 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
SHC1 events in ERBB2 signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Nuclear signaling by ERBB4 pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
ErbB signaling pathway pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
ErbB4 signaling events
ErbB receptor signaling network
Cross-References
SwissProt O14944
TrEMBL
UniProt Splice Variant
Entrez Gene 2069
UniGene Hs.115263 Hs.717956
RefSeq NM_001432
HUGO HGNC:3443
OMIM 602061
CCDS CCDS3564
HPRD
IMGT
EMBL AK314959 BC136404 BC136405 CH471057 CR541887 D30783
GenPept AAI36405 AAI36406 BAA22146 BAG37463 CAG46685 EAX05709
RNA Seq Atlas 2069