Homo sapiens Gene: ACAP1
Summary
InnateDB Gene IDBG-24566.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACAP1
Gene Name ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms CENTB1;
Species Homo sapiens
Ensembl Gene ENSG00000072818
Encoded Proteins
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
ACAP1 (CENTB1) selectively down-regulates NF-kappaB activation via NODs pathways, creating a feedback loop and suggesting a novel role of ACAP1 in innate immune responses to bacteria and inflammatory responses.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7336529-7351478
Strand Forward strand
Band p13.1
Transcripts
ENST00000158762 ENSP00000158762
ENST00000570457 ENSP00000458173
ENST00000570504 ENSP00000460735
ENST00000573893
ENST00000576628
ENST00000574499 ENSP00000460803
ENST00000576594
ENST00000571220
ENST00000571471 ENSP00000461314
ENST00000570439
ENST00000575415 ENSP00000460054
ENST00000575425 ENSP00000459422
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0015031 protein transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016020 membrane
GO:0055038 recycling endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Arf6 trafficking events
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.337242 Hs.606988 Hs.662015
RefSeq NM_014716
HUGO
OMIM
CCDS CCDS11101
HPRD 08474
IMGT
EMBL
GenPept
RNA Seq Atlas