Version 5.4
Homo sapiens Gene: ACAP1
Summary
InnateDB Gene IDBG-24566.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACAP1
Gene Name ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms CENTB1
Species Homo sapiens
Ensembl Gene ENSG00000072818
Encoded Proteins
IDBP-24570
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
IDBP-764283
IDBP-764734
IDBP-759996
IDBP-760807
IDBP-764329
IDBP-762640
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17005562
ACAP1 (CENTB1) selectively down-regulates NF-kappaB activation via NODs pathways, creating a feedback loop and suggesting a novel role of ACAP1 in innate immune responses to bacteria and inflammatory responses.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7336529-7351478
Strand Forward strand
Band p13.1
Transcripts
ENST00000158762 ENSP00000158762
ENST00000570457 ENSP00000458173
ENST00000570504 ENSP00000460735
ENST00000573893
ENST00000576628
ENST00000574499 ENSP00000460803
ENST00000576594
ENST00000571220
ENST00000571471 ENSP00000461314
ENST00000570439
ENST00000575415 ENSP00000460054
ENST00000575425 ENSP00000459422
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0015031 protein transport
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016020 membrane
GO:0055038 recycling endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001588
View Gene Order
ENSBTAG00000010527
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
arf6_traffickingpathway
Arf6 trafficking events
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.337242 Hs.606988 Hs.662015
RefSeq NM_014716
HUGO
OMIM
CCDS CCDS11101
HPRD 08474
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca