|Homo sapiens Gene: CD180|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||CD180 molecule|
|Synonyms||LY64; Ly78; RP105;|
|Useful resources||Stemformatics EHFPI ImmGen|
CD180 is an accessory molecule for TLR2, forming part of the receptor complex for innate immune recognition of mycobacterial lipoproteins.
CD180 and its helper molecule, LY86, interact directly with the TLR4 signalling complex, inhibiting its ability to bind microbial ligands.
CD180 dramatically enhances CpG DNA-induced proliferation/survival by naive B cells but not by memory B cell. This enhancement that is mediated by CD180-induced TLR9 upregulation, leading to Akt activation and sustained NF-kappaB activation.
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 5:67182275-67196799|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
|UniProt Splice Variant|
|RNA Seq Atlas|