Homo sapiens Gene: ADAMTS7
Summary
InnateDB Gene IDBG-25099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAMTS7
Gene Name ADAM metallopeptidase with thrombospondin type 1 motif, 7
Synonyms ADAM-TS 7; ADAM-TS7; ADAMTS-7;
Species Homo sapiens
Ensembl Gene ENSG00000136378
Encoded Proteins
ADAM metallopeptidase with thrombospondin type 1 motif, 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78759203-78811431
Strand Reverse strand
Band q25.1
Transcripts
ENST00000388820 ENSP00000373472
ENST00000568712
ENST00000565793
ENST00000566303
ENST00000569934
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0032331 negative regulation of chondrocyte differentiation
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071773 cellular response to BMP stimulus
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0009986 cell surface
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UKP4
TrEMBL
UniProt Splice Variant
Entrez Gene 11173
UniGene Hs.16441
RefSeq NM_014272 XM_005254137
HUGO HGNC:223
OMIM 605009
CCDS CCDS32303
HPRD 05422
IMGT
EMBL AF140675 AY327122 BC061631
GenPept AAD56358 AAH61631 AAQ94616
RNA Seq Atlas 11173