Homo sapiens Gene: CCNB1
Summary
InnateDB Gene IDBG-25262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNB1
Gene Name cyclin B1
Synonyms CCNB;
Species Homo sapiens
Ensembl Gene ENSG00000134057
Encoded Proteins
cyclin B1
cyclin B1
cyclin B1
cyclin B1
cyclin B1
cyclin B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:69167010-69178245
Strand Forward strand
Band q13.2
Transcripts
ENST00000256442 ENSP00000256442
ENST00000506572 ENSP00000423387
ENST00000508407 ENSP00000426092
ENST00000505500 ENSP00000424588
ENST00000503507 ENSP00000425103
ENST00000507798 ENSP00000426230
ENST00000513102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 138 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 138 [view]
Protein-Protein 126 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005113 patched binding
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0019901 protein kinase binding
GO:0035173 histone kinase activity
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0001556 oocyte maturation
GO:0001701 in utero embryonic development
GO:0001933 negative regulation of protein phosphorylation
GO:0006461 protein complex assembly
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007077 mitotic nuclear envelope disassembly
GO:0007080 mitotic metaphase plate congression
GO:0007283 spermatogenesis
GO:0009612 response to mechanical stimulus
GO:0009636 response to toxic substance
GO:0010629 negative regulation of gene expression
GO:0016572 histone phosphorylation
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0033129 positive regulation of histone phosphorylation
GO:0042246 tissue regeneration
GO:0042493 response to drug
GO:0043148 mitotic spindle stabilization
GO:0045931 positive regulation of mitotic cell cycle
GO:0046680 response to DDT
GO:0048565 digestive tract development
GO:0051301 cell division
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051726 regulation of cell cycle
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore
GO:0055015 ventricular cardiac muscle cell development
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060623 regulation of chromosome condensation
GO:0071174 mitotic spindle checkpoint
GO:0071283 cellular response to iron(III) ion
GO:0071398 cellular response to fatty acid
GO:0071407 cellular response to organic cyclic compound
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0000922 spindle pole
GO:0000942 condensed nuclear chromosome outer kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Hedgehog pathway
REACTOME
Cyclin A/B1 associated events during G2/M transition pathway
Phosphorylation of Emi1 pathway
APC/C-mediated degradation of cell cycle proteins pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
Recruitment of NuMA to mitotic centrosomes pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Condensation of Prophase Chromosomes pathway
Regulation of mitotic cell cycle pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Mitotic G1-G1/S phases pathway
G2/M DNA damage checkpoint pathway
Recruitment of mitotic centrosome proteins and complexes pathway
E2F-enabled inhibition of pre-replication complex formation pathway
G2/M Checkpoints pathway
Nuclear Pore Complex (NPC) Disassembly pathway
G1/S Transition pathway
G2/M DNA replication checkpoint pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Condensation of Prometaphase Chromosomes pathway
Golgi Cisternae Pericentriolar Stack Reorganization pathway
M Phase pathway
Centrosome maturation pathway
E2F mediated regulation of DNA replication pathway
G2/M Transition pathway
Mitotic Prophase pathway
Activation of NIMA Kinases NEK9, NEK6, NEK7 pathway
MASTL Facilitates Mitotic Progression pathway
Cell Cycle, Mitotic pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Mitotic G2-G2/M phases pathway
Polo-like kinase mediated events pathway
Depolymerisation of the Nuclear Lamina pathway
Resolution of Sister Chromatid Cohesion pathway
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
Phosphorylation of the APC/C pathway
Nuclear Envelope Breakdown pathway
Cell Cycle Checkpoints pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
p53 signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
Cell cycle: g2/m checkpoint [Biocarta view]
Sonic hedgehog receptor ptc1 regulates cell cycle [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Estrogen responsive protein efp controls cell cycle and breast tumors growth [Biocarta view]
How progesterone initiates the oocyte maturation [Biocarta view]
Stathmin and breast cancer resistance to antimicrotubule agents [Biocarta view]
Regulation of cell cycle progression by plk3 [Biocarta view]
Cyclins and cell cycle regulation [Biocarta view]
Akap95 role in mitosis and chromosome dynamics [Biocarta view]
PID NCI
Direct p53 effectors
FoxO family signaling
Validated targets of C-MYC transcriptional activation
p73 transcription factor network
C-MYB transcription factor network
FOXM1 transcription factor network
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.23960
RefSeq NM_031966
HUGO
OMIM
CCDS CCDS3997
HPRD 00454
IMGT
EMBL
GenPept
RNA Seq Atlas