Version 5.4
Mus musculus Gene: Arpc4
Summary
InnateDB Gene IDBG-254592.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arpc4
Gene Name actin related protein 2/3 complex, subunit 4
Synonyms 20kDa; 5330419I20Rik; AI327076; p20-Arc
Species Mus musculus
Ensembl Gene ENSMUSG00000079426
Encoded Proteins
IDBP-534454
actin related protein 2/3 complex, subunit 4
IDBP-625470
actin related protein 2/3 complex, subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000241553:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:113378113-113390448
Strand Forward strand
Band E3
Transcripts
ENSMUST00000102708
ENSMUST00000156898 ENSMUSP00000114839
ENSMUST00000138722
ENSMUST00000171058 ENSMUSP00000131690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030674 protein binding, bridging
Biological Process
GO:0008150 biological_process
GO:0030041 actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000241553
View Gene Order
ENSBTAG00000007964
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_230745
Immune System pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_261444
Axon guidance pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188576
Developmental Biology pathway
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_111045
Developmental Biology pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_215545
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_213138
Immune System pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_211475
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_203140
Axon guidance pathway
REACT_259381
EPHB-mediated forward signaling pathway
REACT_216714
Innate Immune System pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.289306 Mm.472172
RefSeq NM_001170485 NM_001170486 NM_026552
OMIM
CCDS CCDS20417 CCDS51871
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca