Version 5.4
Homo sapiens Gene: CDK7
Summary
InnateDB Gene IDBG-25495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK7
Gene Name cyclin-dependent kinase 7
Synonyms CAK1; CDKN7; HCAK; MO15; p39MO15; STK1
Species Homo sapiens
Ensembl Gene ENSG00000134058
Encoded Proteins
IDBP-25499
cyclin-dependent kinase 7
IDBP-481342
cyclin-dependent kinase 7
IDBP-482116
cyclin-dependent kinase 7
IDBP-477463
cyclin-dependent kinase 7
IDBP-475319
cyclin-dependent kinase 7
IDBP-483223
cyclin-dependent kinase 7
IDBP-478018
cyclin-dependent kinase 7
IDBP-478555
cyclin-dependent kinase 7
IDBP-479491
cyclin-dependent kinase 7
IDBP-477030
cyclin-dependent kinase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:69234841-69277430
Strand Forward strand
Band q13.2
Transcripts
ENST00000256443 ENSP00000256443
ENST00000506563 ENSP00000425043
ENST00000512687
ENST00000515391 ENSP00000425893
ENST00000512985
ENST00000515180 ENSP00000426372
ENST00000506789 ENSP00000425983
ENST00000510106 ENSP00000426561
ENST00000514676 ENSP00000422737
ENST00000504147 ENSP00000422027
ENST00000508726 ENSP00000421559
ENST00000502604 ENSP00000422121
ENST00000513629
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 89 [view]
Protein-Protein 85 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0050681 androgen receptor binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000718 nucleotide-excision repair, DNA damage removal
GO:0006200 ATP catabolic process
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006468 protein phosphorylation
GO:0007050 cell cycle arrest
GO:0008283 cell proliferation
GO:0010467 gene expression
GO:0016032 viral process
GO:0030521 androgen receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050434 positive regulation of viral transcription
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005675 holo TFIIH complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000069089
View Gene Order
ENSBTAG00000011046
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_12
BCR pathway
REACTOME
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1470
mRNA Capping pathway
REACT_1655
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_2089
RNA Polymerase II Promoter Escape pathway
REACT_1851
RNA Polymerase II Transcription Initiation pathway
REACT_834
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_975
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6332
HIV Transcription Initiation pathway
REACT_6253
RNA Polymerase II HIV Promoter Escape pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6237
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_1941
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_2222
Dual incision reaction in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_311
Dual incision reaction in GG-NER pathway
REACT_257
Formation of incision complex in GG-NER pathway
REACT_1590
G1 Phase pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_6185
HIV Infection pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_216
DNA Repair pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
KEGG
hsa04110
Cell cycle pathway
hsa03022
Basal transcription factors pathway
hsa03420
Nucleotide excision repair pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
Cross-References
SwissProt
TrEMBL D6R9G1 D6REC6
UniProt Splice Variant
Entrez Gene 1022
UniGene Hs.184298
RefSeq NM_001799
HUGO HGNC:1778
OMIM 601955
CCDS CCDS3999
HPRD 15993
IMGT
EMBL AC145132
GenPept
RNA Seq Atlas 1022

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca