Version 5.4
Homo sapiens Gene: HNRNPC
Summary
InnateDB Gene IDBG-2589.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPC
Gene Name heterogeneous nuclear ribonucleoprotein C (C1/C2)
Synonyms C1; C2; HNRNP; HNRPC; SNRPC
Species Homo sapiens
Ensembl Gene ENSG00000092199
Encoded Proteins
IDBP-2591
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-361010
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-361011
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-600306
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-589078
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-593635
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-597528
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-601192
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-595298
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-598980
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-592712
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-594136
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-589920
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-585227
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-603559
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-594372
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-583121
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-594066
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-603557
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-590093
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-599509
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-586453
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-587233
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-593769
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-599594
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-598629
heterogeneous nuclear ribonucleoprotein C (C1/C2)
IDBP-600245
heterogeneous nuclear ribonucleoprotein C (C1/C2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:21209136-21269494
Strand Reverse strand
Band q11.2
Transcripts
ENST00000336053 ENSP00000338095
ENST00000449098 ENSP00000404559
ENST00000420743 ENSP00000404848
ENST00000430246 ENSP00000442816
ENST00000554969 ENSP00000450725
ENST00000556142 ENSP00000451187
ENST00000554455 ENSP00000451291
ENST00000553753 ENSP00000450548
ENST00000555914 ENSP00000451708
ENST00000555309 ENSP00000450790
ENST00000557442 ENSP00000452599
ENST00000556628 ENSP00000451652
ENST00000555883 ENSP00000450629
ENST00000556513 ENSP00000452214
ENST00000553444
ENST00000557201 ENSP00000452276
ENST00000553300 ENSP00000450544
ENST00000556897 ENSP00000451176
ENST00000557157 ENSP00000450601
ENST00000554539 ENSP00000452545
ENST00000554383 ENSP00000452021
ENST00000555585
ENST00000554417
ENST00000555215 ENSP00000452213
ENST00000555137 ENSP00000452185
ENST00000554891 ENSP00000450467
ENST00000556226 ENSP00000451292
ENST00000555176 ENSP00000452573
ENST00000553614
ENST00000557336 ENSP00000451892
ENST00000557768 ENSP00000450669
ENST00000557033
ENST00000555127
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 173 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 173 [view]
Protein-Protein 169 [view]
Protein-DNA 1 [view]
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0008266 poly(U) RNA binding
GO:0031492 nucleosomal DNA binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0001649 osteoblast differentiation
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043044 ATP-dependent chromatin remodeling
GO:0070935 3'-UTR-mediated mRNA stabilization
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0016020 membrane
GO:0019013 viral nucleocapsid
GO:0030529 ribonucleoprotein complex
GO:0043234 protein complex
GO:0045120 pronucleus
GO:0070062 extracellular vesicular exosome
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000060373
View Gene Order
Pathways
NETPATH
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.459935 Hs.508848 Hs.616536 Hs.622204 Hs.627891 Hs.691932 Hs.700762 Hs.732107 Hs.735530
RefSeq NM_001077442 NM_001077443 NM_004500 NM_031314 XM_006720124 XM_006720125
HUGO
OMIM
CCDS CCDS41915 CCDS45079
HPRD 01243
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca