Homo sapiens Gene: CD68
Summary
InnateDB Gene IDBG-25923.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD68
Gene Name CD68 molecule
Synonyms GP110; LAMP4; SCARD1;
Species Homo sapiens
Ensembl Gene ENSG00000129226
Encoded Proteins
CD68 molecule
CD68 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7579467-7582113
Strand Forward strand
Band p13.1
Transcripts
ENST00000250092 ENSP00000250092
ENST00000380498 ENSP00000369867
ENST00000584502 ENSP00000462768
ENST00000584180 ENSP00000462198
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 3 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3KT24
UniProt Splice Variant
Entrez Gene 968
UniGene Hs.647419
RefSeq NM_001251 NM_001040059
HUGO HGNC:1693
OMIM 153634
CCDS CCDS11114 CCDS58512
HPRD 01093
IMGT
EMBL AC016876
GenPept
RNA Seq Atlas 968