|Homo sapiens Gene: CD68|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||CD68 molecule|
|Synonyms||GP110; LAMP4; SCARD1;|
|Useful resources||Stemformatics EHFPI ImmGen|
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 17:7579467-7582113|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|RNA Seq Atlas||968|