Version 5.4
Mus musculus Gene: C7
Summary
InnateDB Gene IDBG-259737.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C7
Gene Name complement component 7
Synonyms A530026G17; Gm1238
Species Mus musculus
Ensembl Gene ENSMUSG00000079105
Encoded Proteins
IDBP-259739
complement component 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 11058761
[Homo sapiens] Complement component seven is one of five components that interact to form the cytolytic membrane attack complex (MAC)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112936:
C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]
C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:4988762-5063773
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000110689 ENSMUSP00000106317
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006883 cellular sodium ion homeostasis
GO:0006955 immune response
Cellular Component
GO:0005579 membrane attack complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112936
View Gene Order
ENSBTAG00000011766
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04610
Complement and coagulation cascades pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05020
Prion diseases pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_8028
Terminal pathway of complement pathway
REACT_118707
Regulation of Complement cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05020
Prion diseases pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3YXF5
UniProt Splice Variant
Entrez Gene 109828
UniGene Mm.208034
RefSeq NM_001243837
OMIM
CCDS CCDS56974
HPRD
IMGT
MGI ID MGI:88235
MGI Symbol C7
EMBL AC115877 AC131919
GenPept
RNA Seq Atlas 109828

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca