Version 5.4
Homo sapiens Gene: IL16
Summary
InnateDB Gene IDBG-25974.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL16
Gene Name interleukin 16
Synonyms LCF; NIL16; prIL-16; PRIL16
Species Homo sapiens
Ensembl Gene ENSG00000172349
Encoded Proteins
IDBP-744780
IDBP-25982
interleukin 16
IDBP-241106
interleukin 16
IDBP-241114
interleukin 16
IDBP-602361
interleukin 16
IDBP-746757
IDBP-589910
interleukin 16
IDBP-747254
IDBP-586462
interleukin 16
IDBP-588304
interleukin 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:81159575-81314058
Strand Forward strand
Band q25.1
Transcripts
ENST00000360547 ENSP00000456972
ENST00000302987 ENSP00000302935
ENST00000394660 ENSP00000378155
ENST00000394652 ENSP00000378147
ENST00000560989
ENST00000560241 ENSP00000452738
ENST00000559388 ENSP00000458125
ENST00000559383 ENSP00000453250
ENST00000560115 ENSP00000454636
ENST00000560230
ENST00000558857 ENSP00000453131
ENST00000558332 ENSP00000453214
ENST00000559342
ENST00000559953
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 49 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006955 immune response
GO:0016032 viral process
GO:0030595 leukocyte chemotaxis
GO:0050930 induction of positive chemotaxis
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001741
View Gene Order
ENSBTAG00000010963
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL H3BT15
UniProt Splice Variant
Entrez Gene 3603
UniGene Hs.585683
RefSeq XM_005254344 NM_001172128 NM_004513 NM_172217 XM_005254342 XM_005254343 XM_005254345 XM_005254346
HUGO HGNC:5980
OMIM 603035
CCDS CCDS10317 CCDS42069 CCDS53966
HPRD 04329
IMGT
EMBL AC036196 AC103858
GenPept
RNA Seq Atlas 3603

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca