Homo sapiens Gene: OCLN
Summary
InnateDB Gene IDBG-26117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OCLN
Gene Name occludin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197822
Encoded Proteins
occludin
occludin
occludin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:69492292-69558104
Strand Forward strand
Band q13.2
Transcripts
ENST00000355237 ENSP00000347379
ENST00000396442 ENSP00000379719
ENST00000514370
ENST00000510666
ENST00000538151 ENSP00000445940
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 31 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008119 thiopurine S-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0019904 protein domain specific binding
Biological Process
GO:0006461 protein complex assembly
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0032259 methylation
GO:0045216 cell-cell junction organization
GO:0046498 S-adenosylhomocysteine metabolic process
GO:0046500 S-adenosylmethionine metabolic process
GO:0070830 tight junction assembly
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 tight junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0030054 cell junction
GO:0030139 endocytic vesicle
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Apoptotic execution phase pathway
Apoptosis pathway
Apoptotic cleavage of cell adhesion proteins pathway
Apoptotic cleavage of cellular proteins pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Pathogenic Escherichia coli infection pathway
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592605 Hs.610669 Hs.671081
RefSeq NM_001205254 NM_001205255 NM_002538
HUGO
OMIM
CCDS CCDS4006 CCDS54864
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas