InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FOXO1

Summary

InnateDB Gene

IDBG-26475.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXO1

Gene Name

forkhead box O1

Synonyms

FKH1; FKHR; FOXO1A

Species

Homo sapiens

Ensembl Gene

ENSG00000150907

Encoded Proteins

IDBP-26477

forkhead box O1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:40555667-40666597

Strand

Reverse strand

Band

q14.11

Transcripts

ENST00000379561	ENSP00000368880
ENST00000473775

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	62 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0043565	sequence-specific DNA binding
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0001659	temperature homeostasis
GO:0001678	cellular glucose homeostasis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006473	protein acetylation
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009267	cellular response to starvation
GO:0010508	positive regulation of autophagy
GO:0031018	endocrine pancreas development
GO:0032869	cellular response to insulin stimulus
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0034599	cellular response to oxidative stress
GO:0035947	regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042593	glucose homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response
GO:0045444	fat cell differentiation
GO:0045599	negative regulation of fat cell differentiation
GO:0045722	positive regulation of gluconeogenesis
GO:0045732	positive regulation of protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0070417	cellular response to cold
GO:0071455	cellular response to hyperoxia
GO:0071732	cellular response to nitric oxide
GO:2000505	regulation of energy homeostasis