InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Casc3

Summary

InnateDB Gene

IDBG-266574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casc3

Gene Name

cancer susceptibility candidate 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000078676

Encoded Proteins

IDBP-210777

cancer susceptibility candidate 3

IDBP-625129

cancer susceptibility candidate 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108349:
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:98804905-98833814

Strand

Forward strand

Band

Transcripts

ENSMUST00000017384	ENSMUSP00000017384
ENSMUST00000144220
ENSMUST00000147065
ENSMUST00000169695	ENSMUSP00000130926

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006397	mRNA processing
GO:0006417	regulation of translation
GO:0006950	response to stress
GO:0008298	intracellular mRNA localization
GO:0008380	RNA splicing
GO:0051028	mRNA transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016607	nuclear speck
GO:0030529	ribonucleoprotein complex
GO:0035145	exon-exon junction complex
GO:0048471	perinuclear region of cytoplasm