Homo sapiens Gene: ALG10
Summary
InnateDB Gene IDBG-26690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALG10
Gene Name asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139133
Encoded Proteins
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe)
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe)
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:34022281-34029694
Strand Forward strand
Band p11.1
Transcripts
ENST00000266483 ENSP00000266483
ENST00000538927 ENSP00000444084
ENST00000541178
ENST00000541875 ENSP00000443142
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016758 transferase activity, transferring hexosyl groups
Biological Process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0008152 metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
KEGG
N-Glycan biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q5BKT4
TrEMBL F5GZZ6 F5H5T2
UniProt Splice Variant
Entrez Gene 84920
UniGene Hs.609863
RefSeq NM_032834 XM_006719157 XM_006719158
HUGO HGNC:23162
OMIM 603313
CCDS CCDS41769
HPRD
IMGT
EMBL AC046130 AJ312278 AK027657 BC070347 BC090948
GenPept AAH70347 AAH90948 BAB55272 CAC41349
RNA Seq Atlas 84920