Version 5.4
Homo sapiens Gene: FABP4
Summary
InnateDB Gene IDBG-26715.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FABP4
Gene Name fatty acid binding protein 4, adipocyte
Synonyms A-FABP; AFABP; ALBP; aP2; HEL-S-104
Species Homo sapiens
Ensembl Gene ENSG00000170323
Encoded Proteins
IDBP-26717
fatty acid binding protein 4, adipocyte
IDBP-478673
fatty acid binding protein 4, adipocyte
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:81478419-81483263
Strand Reverse strand
Band q21.13
Transcripts
ENST00000256104 ENSP00000256104
ENST00000518669
ENST00000522659 ENSP00000428385
ENST00000521734
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005504 fatty acid binding
Biological Process
GO:0001816 cytokine production
GO:0006469 negative regulation of protein kinase activity
GO:0006810 transport
GO:0019433 triglyceride catabolic process
GO:0042632 cholesterol homeostasis
GO:0044281 small molecule metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050729 positive regulation of inflammatory response
GO:0050872 white fat cell differentiation
GO:0050873 brown fat cell differentiation
GO:0071285 cellular response to lithium ion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005811 lipid particle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062515
View Gene Order
ENSBTAG00000037526
Not yet available
Pathways
NETPATH
REACTOME
REACT_494
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
KEGG
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001442
HUGO
OMIM
CCDS CCDS6230
HPRD 02698
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca