Homo sapiens Gene: HNRNPD
Summary
InnateDB Gene IDBG-26735.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPD
Gene Name heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
Synonyms AUF1; AUF1A; hnRNPD0; HNRPD; P37;
Species Homo sapiens
Ensembl Gene ENSG00000138668
Encoded Proteins
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:82352498-82374503
Strand Reverse strand
Band q21.22
Transcripts
ENST00000313899 ENSP00000313199
ENST00000352301 ENSP00000305860
ENST00000353341 ENSP00000313327
ENST00000514325
ENST00000514671 ENSP00000426446
ENST00000508119
ENST00000513584 ENSP00000424002
ENST00000509263 ENSP00000420926
ENST00000507010 ENSP00000421952
ENST00000515432 ENSP00000426666
ENST00000503822 ENSP00000422615
ENST00000509107 ENSP00000425439
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 231 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 231 [view]
Protein-Protein 206 [view]
Protein-DNA 1 [view]
Protein-RNA 24 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042162 telomeric DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006396 RNA processing
GO:0006401 RNA catabolic process
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0042752 regulation of circadian rhythm
GO:0043488 regulation of mRNA stability
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0097167 circadian regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Splicing pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q14103
TrEMBL A0A024RDF3 D6RAF8 D6RF44 F5H6R6
UniProt Splice Variant
Entrez Gene 3184
UniGene Hs.480073 Hs.732492
RefSeq NM_031370 NM_001003810 NM_002138 NM_031369
HUGO HGNC:5036
OMIM 601324
CCDS CCDS3592 CCDS3590 CCDS3591
HPRD 03206
IMGT
EMBL AC124016 AF026126 AF039575 AK292707 BC002401 BC023977 BC026015 CH471057 D55671 D55672 D55673 D55674 M94630 X03910
GenPept AAA35781 AAB96683 AAC23474 AAC23475 AAC23476 AAH02401 AAH23977 AAH26015 AAY40913 BAA09522 BAA09523 BAA09524 BAA09525 BAF85396 CAA27544 EAX05874 EAX05875 EAX05876
RNA Seq Atlas 3184