Version 5.4
Homo sapiens Gene: SEC31A
Summary
InnateDB Gene IDBG-27208.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC31A
Gene Name SEC31 homolog A (S. cerevisiae)
Synonyms ABP125; ABP130; HSPC334; SEC31L1
Species Homo sapiens
Ensembl Gene ENSG00000138674
Encoded Proteins
IDBP-27212
SEC31 homolog A (S. cerevisiae)
IDBP-27214
SEC31 homolog A (S. cerevisiae)
IDBP-27216
SEC31 homolog A (S. cerevisiae)
IDBP-27218
SEC31 homolog A (S. cerevisiae)
IDBP-239735
SEC31 homolog A (S. cerevisiae)
IDBP-373030
SEC31 homolog A (S. cerevisiae)
IDBP-373033
SEC31 homolog A (S. cerevisiae)
IDBP-478027
SEC31 homolog A (S. cerevisiae)
IDBP-483367
SEC31 homolog A (S. cerevisiae)
IDBP-476138
SEC31 homolog A (S. cerevisiae)
IDBP-475662
SEC31 homolog A (S. cerevisiae)
IDBP-477222
SEC31 homolog A (S. cerevisiae)
IDBP-478722
SEC31 homolog A (S. cerevisiae)
IDBP-476613
SEC31 homolog A (S. cerevisiae)
IDBP-479850
SEC31 homolog A (S. cerevisiae)
IDBP-483943
SEC31 homolog A (S. cerevisiae)
IDBP-482762
SEC31 homolog A (S. cerevisiae)
IDBP-483077
SEC31 homolog A (S. cerevisiae)
IDBP-475299
SEC31 homolog A (S. cerevisiae)
IDBP-483417
SEC31 homolog A (S. cerevisiae)
IDBP-480145
SEC31 homolog A (S. cerevisiae)
IDBP-477678
SEC31 homolog A (S. cerevisiae)
IDBP-479245
SEC31 homolog A (S. cerevisiae)
IDBP-474690
SEC31 homolog A (S. cerevisiae)
IDBP-481885
SEC31 homolog A (S. cerevisiae)
IDBP-474942
SEC31 homolog A (S. cerevisiae)
IDBP-479013
SEC31 homolog A (S. cerevisiae)
IDBP-812899
SEC31 homolog A (S. cerevisiae)
IDBP-473534
SEC31 homolog A (S. cerevisiae)
IDBP-812900
SEC31 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:82818661-82901166
Strand Reverse strand
Band q21.22
Transcripts
ENST00000355196 ENSP00000347329
ENST00000348405 ENSP00000337602
ENST00000311785 ENSP00000309070
ENST00000264405 ENSP00000264405
ENST00000395310 ENSP00000378721
ENST00000448323 ENSP00000400926
ENST00000443462 ENSP00000408027
ENST00000436790
ENST00000513858 ENSP00000426886
ENST00000503937 ENSP00000422371
ENST00000509142 ENSP00000426569
ENST00000505472 ENSP00000421633
ENST00000500777 ENSP00000421464
ENST00000508502 ENSP00000424635
ENST00000515062 ENSP00000426943
ENST00000505479
ENST00000505984 ENSP00000424451
ENST00000511338 ENSP00000425140
ENST00000514362
ENST00000515749
ENST00000509691
ENST00000508479 ENSP00000425999
ENST00000507828 ENSP00000426562
ENST00000512664 ENSP00000424336
ENST00000510167 ENSP00000422267
ENST00000503226
ENST00000512732
ENST00000503058 ENSP00000425056
ENST00000507816 ENSP00000421001
ENST00000514326 ENSP00000425555
ENST00000513323 ENSP00000426950
ENST00000511975
ENST00000507340 ENSP00000422797
ENST00000507867
ENST00000506497
ENST00000510310
ENST00000503210 ENSP00000422563
ENST00000505434 ENSP00000425095
ENST00000507676 ENSP00000475765
ENST00000506495 ENSP00000425064
ENST00000507051 ENSP00000476156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0015031 protein transport
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048208 COPII vesicle coating
GO:0051592 response to calcium ion
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0012507 ER to Golgi transport vesicle membrane
GO:0030120 vesicle coat
GO:0030127 COPII vesicle coat
GO:0030134 ER to Golgi transport vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0070971 endoplasmic reticulum exit site
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035325
View Gene Order
ENSBTAG00000020525
Not yet available
Pathways
NETPATH
REACTOME
REACT_75795
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_12507
COPII (Coat Protein 2) Mediated Vesicle Transport pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_22161
Post-translational protein modification pathway
REACT_11203
ER to Golgi Transport pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370024 Hs.666934 Hs.706121
RefSeq NM_001077206 NM_001077207 NM_001077208 NM_001191049 NM_001300744 NM_001300745 NM_014933 NM_016211 XM_005262850 XM_005262852
HUGO
OMIM
CCDS CCDS3596 CCDS3597 CCDS43244 CCDS47088 CCDS54773 CCDS75155 CCDS75156
HPRD 15314
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca