Version 5.4
Homo sapiens Gene: LRRK2
Summary
InnateDB Gene IDBG-27257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRK2
Gene Name leucine-rich repeat kinase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188906
Encoded Proteins
IDBP-27259
leucine-rich repeat kinase 2
IDBP-27263
leucine-rich repeat kinase 2
IDBP-372124
leucine-rich repeat kinase 2
IDBP-372194
leucine-rich repeat kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21983832
LRRK2 acts as a potent negative regulator of the transcription factor NFAT, and plays an important role in modulating inflammatory bowel disease.
InnateDB Annotation from Orthologs
Summary
PMID 21983832
[Mus musculus] Lrrk2 acts as a potent negative regulator of the transcription factor NFAT, and plays an important role in modulating inflammatory bowel disease. Lrrk2 deficiency conferred enhanced susceptibility to experimental colitis in mice.
Entrez Gene
Summary This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:40196744-40369285
Strand Forward strand
Band q12
Transcripts
ENST00000343742 ENSP00000341930
ENST00000298910 ENSP00000298910
ENST00000416796 ENSP00000398726
ENST00000430804 ENSP00000410821
ENST00000474202
ENST00000479187
ENST00000481256
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 361 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 361 [view]
Protein-Protein 361 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0001948 glycoprotein binding
GO:0003779 actin binding
GO:0003924 GTPase activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004857 enzyme inhibitor activity
GO:0005096 GTPase activator activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0015631 tubulin binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
GO:0017075 syntaxin-1 binding
GO:0030276 clathrin binding
GO:0034211 GTP-dependent protein kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044325 ion channel binding
GO:0051018 protein kinase A binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0006184 GTP catabolic process
GO:0006468 protein phosphorylation
GO:0006914 autophagy
GO:0006979 response to oxidative stress
GO:0007264 small GTPase mediated signal transduction
GO:0007528 neuromuscular junction development
GO:0008340 determination of adult lifespan
GO:0010508 positive regulation of autophagy
GO:0010738 regulation of protein kinase A signaling
GO:0014041 regulation of neuron maturation
GO:0015031 protein transport
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0021772 olfactory bulb development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0031398 positive regulation of protein ubiquitination
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034260 negative regulation of GTPase activity
GO:0034613 cellular protein localization
GO:0035556 intracellular signal transduction
GO:0035564 regulation of kidney size
GO:0035640 exploration behavior
GO:0035641 locomotory exploration behavior
GO:0040012 regulation of locomotion
GO:0042391 regulation of membrane potential
GO:0043068 positive regulation of programmed cell death
GO:0043547 positive regulation of GTPase activity
GO:0045087 innate immune response (InnateDB)
GO:0046777 protein autophosphorylation
GO:0048312 intracellular distribution of mitochondria
GO:0048812 neuron projection morphogenesis
GO:0051900 regulation of mitochondrial depolarization
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060159 regulation of dopamine receptor signaling pathway
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0061001 regulation of dendritic spine morphogenesis
GO:0070997 neuron death
GO:0071407 cellular response to organic cyclic compound
GO:1901214 regulation of neuron death
GO:1902692 regulation of neuroblast proliferation
GO:1902803 regulation of synaptic vesicle transport
GO:1902823 negative regulation of late endosome to lysosome transport
GO:1903125 negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
GO:2000172 regulation of branching morphogenesis of a nerve
GO:2000300 regulation of synaptic vesicle exocytosis
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005764 lysosome
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016234 inclusion body
GO:0030424 axon
GO:0030425 dendrite
GO:0031410 cytoplasmic vesicle
GO:0031966 mitochondrial membrane
GO:0032473 external side of mitochondrial outer membrane
GO:0032839 dendrite cytoplasm
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036273
View Gene Order
ENSBTAG00000016260
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05012
Parkinson's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.187636 Hs.630869
RefSeq NM_198578 XM_005268629
HUGO
OMIM
CCDS CCDS31774
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca