Homo sapiens Gene: TRIM6
Summary
InnateDB Gene IDBG-27325.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM6
Gene Name tripartite motif containing 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121236
Encoded Proteins
tripartite motif containing 6
tripartite motif containing 6
tripartite motif containing 6
tripartite motif containing 6
tripartite motif containing 6
tripartite motif containing 6
tripartite motif containing 6
tripartite motif containing 6
tripartite motif containing 6
tripartite motif containing 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TRIM6 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:5596109-5612958
Strand Forward strand
Band p15.4
Transcripts
ENST00000278302 ENSP00000278302
ENST00000380107 ENSP00000369450
ENST00000380097 ENSP00000369440
ENST00000424369 ENSP00000414108
ENST00000445329 ENSP00000399215
ENST00000507320 ENSP00000427704
ENST00000511284
ENST00000506134 ENSP00000421079
ENST00000515022 ENSP00000421802
ENST00000469187
ENST00000481603
ENST00000621176 ENSP00000484009
ENST00000618326 ENSP00000480315
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0070206 protein trimerization
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Cross-References
SwissProt Q9C030
TrEMBL C9JNQ0
UniProt Splice Variant
Entrez Gene 117854
UniGene
RefSeq NM_001198644 NM_001198645 NM_058166 NM_001003818
HUGO HGNC:16277
OMIM 607564
CCDS CCDS55738 CCDS31390 CCDS31389
HPRD 12123
IMGT
EMBL AB039903 AC015691 AF220030 AK027664 AK290172 AK293295 AK298301 AK316178 AK316289 BC047564 CH471064
GenPept AAG53484 AAH47564 BAB17050 BAB55276 BAF82861 BAG56816 BAG60556 BAH14549 BAH14660 EAW68783 EAW68785
RNA Seq Atlas 117854