Homo sapiens Gene: KEAP1
Summary
InnateDB Gene IDBG-27562.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KEAP1
Gene Name kelch-like ECH-associated protein 1
Synonyms INrf2; KLHL19;
Species Homo sapiens
Ensembl Gene ENSG00000079999
Encoded Proteins
kelch-like ECH-associated protein 1
kelch-like ECH-associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Phosphorylation of Sqstm1 (p62) activates the Keap1-Nrf2 pathway during selective autophagy
Entrez Gene
Summary This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10486120-10503741
Strand Reverse strand
Band p13.2
Transcripts
ENST00000171111 ENSP00000171111
ENST00000393623 ENSP00000377245
ENST00000590237
ENST00000591419 ENSP00000465126
ENST00000592055 ENSP00000468671
ENST00000590593 ENSP00000467601
ENST00000591039 ENSP00000465024
ENST00000588024
ENST00000592478 ENSP00000468014
ENST00000585845 ENSP00000466704
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 115 [view]
Protein-Protein 112 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0016567 protein ubiquitination
GO:0045604 regulation of epidermal cell differentiation
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005815 microtubule organizing center
GO:0030496 midbody
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
Oxidative stress induced gene expression via nrf2 [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.465870
RefSeq NM_012289 NM_203500 XM_005260173
HUGO
OMIM
CCDS CCDS12239
HPRD 12079
IMGT
EMBL
GenPept
RNA Seq Atlas