Version 5.4
Homo sapiens Gene: TRIM5
Summary
InnateDB Gene IDBG-27690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM5
Gene Name tripartite motif containing 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132256
Encoded Proteins
IDBP-27692
tripartite motif containing 5
IDBP-27696
tripartite motif containing 5
IDBP-236622
tripartite motif containing 5
IDBP-364274
tripartite motif containing 5
IDBP-364277
tripartite motif containing 5
IDBP-364288
tripartite motif containing 5
IDBP-364297
tripartite motif containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21131187
TRIM5 is upregulated by Type I and Type II interferons and have been found to restrict viral replication by modulating the RIG-I pathway.
PMID 21734563
TRIM5 is an innate intracellular HIV restriction factor that is upregulated by type I interferons.
PMID 23438823
TRIM5 was identified in a systematic screen for positive regulators of innate immune responses.
PMID 26101372
TRIM5 requires UBE2W, UBE2N and UBE2V2 enzymatic activities to inhibit retroviral DNA synthesis
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:5663557-5938619
Strand Reverse strand
Band p15.4
Transcripts
ENST00000380034 ENSP00000369373
ENST00000380027 ENSP00000369366
ENST00000396847 ENSP00000380058
ENST00000433961 ENSP00000393052
ENST00000438025 ENSP00000398196
ENST00000412903 ENSP00000388031
ENST00000419850 ENSP00000388150
ENST00000483835
ENST00000492086
ENST00000465634
ENST00000487241
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
Experimentally validated
Total 53 [view]
Protein-Protein 52 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008329 signaling pattern recognition receptor activity
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0002218 activation of innate immune response
GO:0002221 pattern recognition receptor signaling pathway
GO:0016032 viral process
GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response (InnateDB)
GO:0046597 negative regulation of viral entry into host cell
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0070206 protein trimerization
GO:0070534 protein K63-linked ubiquitination
GO:1902187 negative regulation of viral release from host cell
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_033034 NM_033092 NM_033093 XM_005253183 XM_005253184 XM_006718358
HUGO
OMIM
CCDS CCDS31392 CCDS31393 CCDS31394
HPRD 07004
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca