Homo sapiens Gene: KAT8
Summary
InnateDB Gene IDBG-27798.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KAT8
Gene Name K(lysine) acetyltransferase 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103510
Encoded Proteins
K(lysine) acetyltransferase 8
K(lysine) acetyltransferase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:31115754-31131393
Strand Forward strand
Band p11.2
Transcripts
ENST00000219797 ENSP00000219797
ENST00000448516 ENSP00000406037
ENST00000543774 ENSP00000456933
ENST00000539683
ENST00000538768
ENST00000537402 ENSP00000454592
ENST00000573144
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 59 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 7 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016407 acetyltransferase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0019899 enzyme binding
GO:0035064 methylated histone binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046872 metal ion binding
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
Biological Process
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016573 histone acetylation
GO:0030099 myeloid cell differentiation
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0031965 nuclear membrane
GO:0071339 MLL1 complex
GO:0072487 MSL complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
p53 pathway
Cross-References
SwissProt Q9H7Z6
TrEMBL
UniProt Splice Variant
Entrez Gene 84148
UniGene Hs.533803 Hs.640371
RefSeq NM_032188 NM_182958
HUGO HGNC:17933
OMIM 609912
CCDS CCDS10706 CCDS45468
HPRD
IMGT
EMBL AC009088 AC135050 AF217501 AF260665 AF289578 AK021872 AK024102 AK291106 AL050395 BC037773 CH471192
GenPept AAF72665 AAH37773 AAL55762 AAL56648 BAB13924 BAB14827 BAF83795 CAH56416 EAW52157 EAW52158
RNA Seq Atlas 84148